Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer's Prevention study

被引：49

作者：

Clark, Lindsay R. ^{[1
,2
]}

Racine, Annie M. ^{[2
,3
,4
]}

Koscik, Rebecca L. ^{[1
]}

Okonkwo, Ozioma C. ^{[1
,2
,5
]}

Engelman, Corinne D. ^{[1
,6
]}

Carlsson, Cynthia M. ^{[1
,2
,5
]}

Asthana, Sanjay ^{[1
,2
,5
]}

Bendlin, Barbara B. ^{[2
,5
]}

Chappell, Rick ^{[7
,8
]}

Nicholas, Christopher R. ^{[2
,5
]}

Rowley, Howard A. ^{[2
,9
]}

Oh, Jennifer M. ^{[2
,5
]}

Hermann, Bruce P. ^{[1
,10
]}

Sager, Mark A. ^{[1
]}

Christian, Bradley T. ^{[11
,12
,13
]}

Johnson, Sterling C. ^{[1
,2
,3
,12
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Wisconsin Alzheimers Inst, Madison, WI 53706 USA

[2] Univ Wisconsin, Sch Med & Publ Hlth, Alzheimers Dis Res Ctr, Madison, WI 53706 USA

[3] Univ Wisconsin, Inst Aging, Madison, WI USA

[4] Univ Wisconsin, Neurosci & Publ Policy Program, Madison, WI USA

[5] Wm S Middleton Vet Hosp, Geriatr Res Educ & Clin Ctr, Madison, WI USA

[6] Univ Wisconsin, Sch Med & Publ Hlth, Dept Populat Hlth Sci, Madison, WI USA

[7] Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI USA

[8] Univ Wisconsin, Dept Stat, Madison, WI 53706 USA

[9] Univ Wisconsin, Dept Radiol, Sch Med & Publ Hlth, Madison, WI 53706 USA

[10] Univ Wisconsin, Dept Neurol, Sch Med & Publ Hlth, Madison, WI 53706 USA

[11] Univ Wisconsin, Dept Med Phys, Sch Med & Publ Hlth, 1530 Med Sci Ctr, Madison, WI 53706 USA

[12] Univ Wisconsin, Waisman Lab Brain Imaging & Behav, Madison, WI USA

[13] Univ Wisconsin, Dept Psychiat, Sch Med & Publ Hlth, Madison, WI 53706 USA

来源：

Alzheimers & Dementia | 2016年 / 12卷 / 07期

关键词：

Alzheimer's disease; Amyloid imaging; Preclinical Alzheimer's disease; Mild cognitive impairment; Cognition; APOE; HEALTHY OLDER-ADULTS; A-BETA; EPISODIC MEMORY; NONDEMENTED INDIVIDUALS; APOLIPOPROTEIN-E; APOE GENOTYPE; DISEASE; DEPOSITION; BURDEN; IMPAIRMENT;

D O I：

10.1016/j.jalz.2015.12.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: The present study investigated the relationship between beta-amyloid (Ab) and cognition in a late middle-aged cohort at risk for Alzheimer's disease (AD). Methods: One eighty-four participants (mean age 5 60; 72% parental history of AD) completed a [C-11] Pittsburgh compound B positron emission tomography scan and serial cognitive evaluations. A global measure of Ab burden was calculated, and composite scores assessing learning, delayed memory, and executive functioning were computed. Results: Higher A beta was associated with classification of psychometric mild cognitive impairment(MCI) at follow-up (P < .01). Linear mixed effects regression results indicated higher Ab was associated with greater rates of decline in delayed memory (P < .01) and executive functioning (P < .05). Apolipoprotein E (APOE) epsilon 4 status moderated the relationship between Ab and cognitive trajectories (P values,. 01). Discussion: In individuals at risk for AD, greater Ab in late middle age is associated with increased likelihood of MCI at follow-up and steeper rates of cognitive decline. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：805 / 814

页数：10

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