The effects of interferon alpha-2b in combination with ribavirin on health related quality of life and work productivity

被引:186
作者
McHutchison, JG
Ware, JE
Bayliss, MS
Pianko, S
Albrecht, JK
Cort, S
Yang, I
Neary, MP
机构
[1] Scripps Res Inst, La Jolla, CA 92037 USA
[2] Qual Metr Inc, Lincoln, RI USA
[3] Hlth Assessment Lab, Boston, MA USA
[4] Tufts Univ, Sch Med, Boston, MA 02111 USA
[5] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA
[6] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA
关键词
health-related quality of life; SF-36 health survey; hepatitis C treatment; hepatitis quality-of-life questionnaire; interferon; ribavirin; combination therapy; work productivity;
D O I
10.1016/S0168-8278(00)00026-X
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: Interferon plus ribavirin is the most effective therapy for chronic hepatitis C. The aim of this study was to evaluate the effect of chronic hepatitis C and therapy on health-related quality of life and work functioning. Methods: Nine hundred and twelve patients with hepatitis C infection were randomized in a controlled trial of Interferon alpha 2b 3 MU tiw for 24 or 48 weeks plus ribavirin 1000-1200 mg or placebo, Questionnaire-based assessments of health-related quality of life and work functioning were performed before, during, and after treatment. Outcome measures included the SF-36 Health Survey and additional generic and specific scales. Work functioning was assessed as missed days, shorter hours or less productivity at work. Results: Pre-treatment, patients had significant impairment in five of eight SF-36 concepts compared to matched population norms. Sustained responders had a return to normal for four of these five concepts. Quality of life did not improve in non-responders. Improvements in histology, viral load or ALT values predicted improvements in quality of life. Sustained responders also had improvements in work functioning and productivity, Conclusions: Hepatitis C patients had impaired quality of life. After combination therapy, sustained virologic responders achieved benefits in their quality of life and work functioning. (C) 2001 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:140 / 147
页数:8
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