Synthesis and evaluation of a bicyclic deoxymannojirimycin derivative as a potential glycosidase inhibitor

被引：15

作者：

Tanaka, KSE ^{[1
]}

Bennet, AJ ^{[1
]}

机构：

[1] Simon Fraser Univ, Dept Chem, Burnaby, BC V5A 1S6, Canada

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1998年 / 76卷 / 04期

关键词：

glycosidase; inhibitor; bicyclic; deoxymannojirimycin; deoxynojirimycin;

D O I：

10.1139/cjc-76-4-431

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A bicyclo[2.2.2] analogue of the glycosidase inhibitor 1-deoxynojirimycin, 2,6-anhydro-l-deoxymannojirimycin (6), has been synthesized in nine steps from I,5-anhydro-D-glucitol. This conformationally restricted aza-sugar has been shown to inhibit, albeit weakly, several glycosidase enzymes.

引用

页码：431 / 436

页数：6

共 36 条

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