Reversible altered consciousness with brain atrophy caused by valproic acid

被引：7
作者：
Yamanouchi, H
Ota, T
Imataka, G
Nakagawa, E
Eguchi, M
机构：
[1] Dokkyo Univ, Sch Med, Dept Pediat, Shimotsuga, Tochigi 3210293, Japan
[2] Shimotsuga Gen Hosp, Dept Pediat, Tochigi, Japan
来源：
PEDIATRIC NEUROLOGY | 2003年 / 28卷 / 05期
关键词：
D O I：
10.1016/S0887-8994(03)00005-5
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A 5-year-old female developed alteration of consciousness during 3 days of long-term treatment with valproic acid for localization-related epilepsy. Computed tomography revealed cerebral atrophy, and electroencephalography presented slow background activity. Consciousness cleared only 12 hours after valproic acid was discontinued, and normal electroencephalography results were evident 1 week later. Cerebral atrophy was nonexistent 2 months later. This rapidly developing but reversible alteration of consciousness in parallel with brain atrophy is recognized as a rare idiosyncratic adverse effect of valproic acid. (C) 2003 by Elsevier Inc. All rights reserved.
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页码：382 / 384
页数：3
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