Assessment of local angiogenesis and vascular endothelial growth factor in the patients with atrophic-erosive and reticular oral lichen planus

被引：65
作者：
Tao, Xiaoan
Huang, Yulei
Li, Ruyao
Qing, Ronghui
Ma, Li
Rhodus, Nelson L.
Cheng, Bin
机构：
[1] Sun Yat Sen Univ, Sch Stomatol, Dept Oral Med, Guangzhou 510060, Peoples R China
[2] Sun Yat Sen Univ, Guangzhou, Peoples R China
[3] Univ Minnesota, Minneapolis, MN USA
[4] Sun Yat Sen Univ, Sch Stomatol, Dept Oral Pathol, Guangzhou, Peoples R China
[5] Univ Minnesota, Sch Dent, Dept Diagnost & Surg Sci, Div Oral Med, Minneapolis, MN 55455 USA
来源：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY | 2007年 / 103卷 / 05期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.tripleo.2006.05.023
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Objectives. The objective of this study was to assess local angiogenesis and expression of VEGF in atrophic- erosive and reticular oral lichen planus (OLP). Study design. Microvessel density (MVD) and VEGF level in 30 OLP subjects and 7 matched controls were detected by immunohistochemistry and ELISA. Results. MVD and VEGF levels in whole OLP group were significantly elevated (P = .033, P < .0001, respectively), and there was a positive correlation between MVD and VEGF (correlation coefficient = 0.84, P < .0001). MVD in atrophic-erosive OLP was significantly higher than that in controls (P = .001) and reticular OLP (P = .042), and the expression of VEGF in both subgroups was significantly higher (P < .0001, P < .008, respectively) compared to control group. Conclusion. These results indicated that angiogenesis and VEGF expression were closely correlated to the different clinical forms of OLP lesions, which may give new insights into the mechanisms and treatment strategy of OLP.
引用
收藏
页码：661 / 669
页数：9
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