Mechanical behavior of polymer-based vs. metallic-based bioresorbable stents

被引:68
作者
Ang, Hui Ying [1 ]
Huang, Ying Ying [2 ]
Lim, Soo Teik [1 ,3 ]
Wong, Philip [1 ,3 ]
Joner, Michael [4 ]
Foin, Nicolas [1 ]
机构
[1] Natl Heart Ctr Singapore, Singapore, Singapore
[2] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore, Singapore
[3] Duke NUS Med Sch, Singapore, Singapore
[4] Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany
关键词
Bioresorbable stents; coronary artery disease; coronary stents; bioresorbable scaffolds (BRS); magnesium (Mg) stents; bioresorbable vascular scaffold (BVS); CORONARY-ARTERY-DISEASE; SIROLIMUS-ELUTING STENT; VASCULAR SCAFFOLD; ABSORB II; BIODEGRADABLE METALS; MAGNESIUM; IMPLANTATION; OUTCOMES; DESIGN; BENCH;
D O I
10.21037/jtd.2017.06.30
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Bioresorbable scaffolds (BRS) were developed to overcome the drawbacks of current metallic drug-eluting stents (DES), such as late in-stent restenosis and caging of the vessel permanently. The concept of the BRS is to provide transient support to the vessel during healing before being degraded and resorbed by the body, freeing the vessel and restoring vasomotion. The mechanical properties of the BRS are influenced by the choice of the material and processing methods. Due to insufficient radial strength of the bioresorbable material, BRS often required large strut profile as compared to conventional metallic DES. Having thick struts will in turn affect the deliverability of the device and may cause flow disturbance, thereby increasing the incidence of acute thrombotic events. Currently, the bioresorbable poly-l-lactic acid (PLLA) polymer and magnesium (Mg) alloys are being investigated as materials in BRS technologies. The bioresorption process, mechanical properties, in vitro observations and clinical outcomes of PLLA-based and Mg-based BRS will be examined in this review.
引用
收藏
页码:S923 / S934
页数:12
相关论文
共 64 条
[1]   Materials and Manufacturing Technologies Available for Production of a Pediatric Bioabsorbable Stent [J].
Alexy, Ryan D. ;
Levi, Daniel S. .
BIOMED RESEARCH INTERNATIONAL, 2013, 2013
[2]   Bioresorbable stents: Current and upcoming bioresorbable technologies [J].
Ang, Hui Ying ;
Bulluck, Heerajnarain ;
Wong, Philip ;
Venkatraman, Subbu S. ;
Huang, Yingying ;
Foin, Nicolas .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2017, 228 :931-939
[3]  
Berglund Joseph, 2009, EuroIntervention, V5 Suppl F, pF72, DOI 10.4244/EIJV5IFA12
[4]   Bioresorbable scaffolds: Current knowledge, potentialities and limitations experienced during their first clinical applications [J].
Bourantas, Christos V. ;
Onuma, Yoshinobu ;
Farooq, Vasim ;
Zhang, Yaojun ;
Garcia-Garcia, Hector M. ;
Serruys, Patrick W. .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2013, 167 (01) :11-21
[5]   Biodegradable Metals for Cardiovascular Stents: from Clinical Concerns to Recent Zn-Alloys [J].
Bowen, Patrick K. ;
Shearier, Emily R. ;
Zhao, Shan ;
Guillory, Roger J., II ;
Zhao, Feng ;
Goldman, Jeremy ;
Drelich, Jaroslaw W. .
ADVANCED HEALTHCARE MATERIALS, 2016, 5 (10) :1121-1140
[6]   Bioresorbable Drug-Eluting Magnesium-Alloy Scaffold for Treatment of Coronary Artery Disease [J].
Campos, Carlos M. ;
Muramatsu, Takashi ;
Iqbal, Javaid ;
Zhang, Ya-Jun ;
Onuma, Yoshinobu ;
Garcia-Garcia, Hector M. ;
Haude, Michael ;
Lemos, Pedro A. ;
Warnack, Boris ;
Serruys, Patrick W. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (12) :24492-24500
[7]   Mechanical properties of the everolimus-eluting bioresorbable vascular scaffold compared to the metallic everolimus-eluting stent [J].
Dalos, Daniel ;
Gangl, Clemens ;
Roth, Christian ;
Krenn, Lisa ;
Scherzer, Sabine ;
Vertesich, Markus ;
Lang, Irene ;
Maurer, Gerald ;
Neunteufl, Thomas ;
Berger, Rudolf ;
Delle-Karth, Georg .
BMC CARDIOVASCULAR DISORDERS, 2016, 16
[8]  
Ellis SG, 2017, ACC FLOR US
[9]   Everolimus-Eluting Bioresorbable Scaffolds for Coronary Artery Disease [J].
Ellis, Stephen G. ;
Kereiakes, Dean J. ;
Metzger, D. Christopher ;
Caputo, Ronald P. ;
Rizik, David G. ;
Teirstein, Paul S. ;
Litt, Marc R. ;
Kini, Annapoorna ;
Kabour, Ameer ;
Marx, Steven O. ;
Popma, Jeffrey J. ;
McGreevy, Robert ;
Zhang, Zhen ;
Simonton, Charles ;
Stone, Gregg W. .
NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (20) :1905-1915
[10]   Current bioresorbable scaffold technologies for treatment of coronary artery diseases: Do polymer and Magnesium platforms differ? [J].
Foin, Nicolas ;
Ng, Jaryl ;
Wong, Philip ;
Di Mario, Carlo .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2016, 223 :526-528