No Association between TERT-CLPTM1L Single Nucleotide Polymorphism rs401681 and Mean Telomere Length or Cancer Risk

被引:39
作者
Pooley, Karen A. [1 ]
Tyrer, Jonathan [2 ]
Shah, Mitul [2 ]
Driver, Kristy E. [2 ]
Leyland, Jean
Brown, Judith
Audley, Tina
McGuffog, Lesley
Ponder, Bruce A. J. [3 ]
Pharoah, Paul D. P. [2 ]
Easton, Douglas F.
Dunning, Alison M. [2 ]
机构
[1] Strangeways Res Lab, Dept Publ Hlth & Primary Care, Canc Res UK Genet Epidemiol Unit, Cambridge CB1 8RN, England
[2] Strangeways Res Lab, Dept Oncol, Cambridge CB1 8RN, England
[3] Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge, England
关键词
GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; VARIANTS; SEQUENCE;
D O I
10.1158/1055-9965.EPI-10-0281
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: A recent study reported genetic variants in the TERT-CLPTM1L locus that were associated with mean telomere length, and with risk of multiple cancers. Methods: We evaluated the association between single nucleotide polymorphism (SNP) rs401681 (C > T) and mean telomere length, using quantitative real-time PCR, in blood-extracted DNA collected from 11,314 cancer-free participants from the Sisters in Breast Screening study, the Melanoma and Pigmented Lesions Evaluative Study melanoma family study, and the SEARCH Breast, Colorectal, Melanoma studies. We also examined the relationship between rs401618 genotype and susceptibility to breast cancer (6,800 cases and 6,608 controls), colorectal cancer (2,259 cases and 2,181 controls), and melanoma (787 cases and 999 controls). Results: The "per T allele" change in mean telomere length (Delta Ct), adjusted for age, study plate, gender, and family was 0.001 [95% confidence intervals (CI), 0.01-0.02; P trend = 0.61]. The "per T allele" odds ratio for each cancer was 1.01 for breast cancer (95% CI, 0.96-1.06; P trend = 0.64), 1.02 for colorectal cancer (95% CI, 0.94-1.11; P trend = 0.66), and 0.99 for melanoma (95% CI, 0.84-1.15; P trend = 0.87). Conclusions: We found no evidence that this SNP was associated with mean telomere length, or with risk of breast cancer, colorectal cancer, or melanoma. Impact: Our results indicate that the observed associations between rs401681 and several cancer types might be weaker than previously described. The lack of an association in our study between this SNP and mean telomere length suggests that any association with cancer risk at this locus is not mediated through TERT. Cancer Epidemiol Biomarkers Prev; 19(7); 1862-5. (C) 2010 AACR.
引用
收藏
页码:1862 / 1865
页数:4
相关论文
共 50 条
[21]   The interaction effects of polycyclic aromatic hydrocarbons exposure and TERT-CLPTM1L variants on longitudinal telomere length shortening: A prospective cohort study [J].
Fu, Wenshan ;
Chen, Zhuowang ;
Bai, Yansen ;
Wu, Xiulong ;
Li, Guyanan ;
Chen, Weilin ;
Wang, Gege ;
Wang, Suhan ;
Li, Xiaoliang ;
He, Meian ;
Zhang, Xiaomin ;
Wu, Tangchun ;
Guo, Huan .
ENVIRONMENTAL POLLUTION, 2018, 242 :2100-2110
[22]   Genetic Variations in TERT-CLPTM1L Genes and Risk of Lung Cancer in Chinese Women Nonsmokers [J].
Li, Cheng ;
Yin, Zhihua ;
Wu, Wei ;
Li, Xuelian ;
Ren, Yangwu ;
Zhou, Baosen .
PLOS ONE, 2013, 8 (05)
[23]   Association of single nucleotide polymorphism rs6983267 with the risk of prostate cancer [J].
Yang, Yuan ;
Wang, Wenjing ;
Zhang, Liangcai ;
Zhang, Shihua ;
Liu, Guiyou ;
Yu, Yingcui ;
Liao, Mingzhi .
ONCOTARGET, 2016, 7 (18) :25528-25534
[24]   Association of single nucleotide polymorphism rs3803662 with the risk of breast cancer [J].
Yang, Yuan ;
Wang, Wenjing ;
Liu, Guiyou ;
Yu, Yingcui ;
Liao, Mingzhi .
SCIENTIFIC REPORTS, 2016, 6
[25]   Significant association of 5p15.33 (TERT-CLPTM1L genes) with lung cancer in Chinese Han population [J].
Zhao, Zhenhong ;
Li, Cong ;
Yang, Lixin ;
Zhang, Xiaobo ;
Zhao, Xueying ;
Song, Xiao ;
Li, Xiaoying ;
Wang, Jiucun ;
Qian, Ji ;
Yang, Yajun ;
Jin, Li ;
Chen, Hongyan ;
Lu, Daru .
EXPERIMENTAL LUNG RESEARCH, 2013, 39 (02) :91-98
[26]   A single nucleotide polymorphism in CYP1B1 leads to differential prostate cancer risk and telomere length [J].
Gu, Cheng-Yuan ;
Li, Gao-Xiang ;
Zhu, Yu ;
Xu, Hua ;
Zhu, Yao ;
Qin, Xiao-Jian ;
Bo, Dai ;
Ye, Ding-Wei .
JOURNAL OF CANCER, 2018, 9 (02) :269-274
[27]   Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk [J].
Carvajal-Carmona, Luis G. ;
O'Mara, Tracy A. ;
Painter, Jodie N. ;
Lose, Felicity A. ;
Dennis, Joe ;
Michailidou, Kyriaki ;
Tyrer, Jonathan P. ;
Ahmed, Shahana ;
Ferguson, Kaltin ;
Healey, Catherine S. ;
Pooley, Karen ;
Beesley, Jonathan ;
Cheng, Timothy ;
Jones, Angela ;
Howarth, Kimberley ;
Martin, Lynn ;
Gorman, Maggie ;
Hodgson, Shirley ;
Wentzensen, Nicholas ;
Fasching, Peter A. ;
Hein, Alexander ;
Beckmann, Matthias W. ;
Renner, Stefan P. ;
Doerk, Thilo ;
Hillemanns, Peter ;
Duerst, Matthias ;
Runnebaum, Ingo ;
Lambrechts, Diether ;
Coenegrachts, Lieve ;
Schrauwen, Stefanie ;
Amant, Frederic ;
Winterhoff, Boris ;
Dowdy, Sean C. ;
Goode, Ellen L. ;
Teoman, Attila ;
Salvesen, Helga B. ;
Trovik, Jone ;
Njolstad, Tormund S. ;
Werner, Henrica M. J. ;
Scott, Rodney J. ;
Ashton, Katie ;
Proietto, Tony ;
Otton, Geoffrey ;
Wersaell, Ofra ;
Mints, Miriam ;
Tham, Emma ;
Hall, Per ;
Czene, Kamila ;
Liu, Jianjun ;
Li, Jingmei .
HUMAN GENETICS, 2015, 134 (02) :231-245
[28]   TERT-rs33963617 and CLPTM1L-rs77518573 reduce the risk of non-small cell lung cancer in Chinese population [J].
Ji, Zhi ;
Li, Ying ;
Xiang, Cheng ;
Luo, Xia ;
Yuan, Peihong ;
Long, Jieyi ;
Shen, Na ;
Shen, Ying ;
Deng, Lingyan ;
Li, Jiaoyuan ;
Cheng, Liming .
GENE, 2020, 731
[29]   Association of TERT-CLPTM1L and 8q24 Common Genetic Variants with Gallbladder Cancer Susceptibility and Prognosis in North Indian Population [J].
Yadav, Saurabh ;
Chandra, Abhijit ;
Kumar, Ashok ;
Mittal, Balraj .
BIOCHEMICAL GENETICS, 2018, 56 (04) :267-282
[30]   The updated relationship between the cleft-lip and palate transmembrane protein-1-like rs401681 and lung cancer risk: A systematic review and meta-analysis [J].
Fang, Zemin ;
Zhao, Gaofeng ;
Wang, Yuebin ;
Li, Fengke ;
Ding, Zhidan .
MOLECULAR AND CLINICAL ONCOLOGY, 2024, 21 (04)