Heterochromatin dysregulation in human diseases

被引：30
作者：
Hahn, Matthias
Dambacher, Silvia
Schotta, Gunnar [1 ]
机构：
[1] Ludwig Maximilians Univ Munchen, Adolf Butenandt Inst, D-80336 Munich, Germany
来源：
JOURNAL OF APPLIED PHYSIOLOGY | 2010年 / 109卷 / 01期
关键词：
epigenetics; heterochromatin; epigenetic therapy; FSHD; FRDA; cancer; FACIOSCAPULOHUMERAL MUSCULAR-DYSTROPHY; PRADER-WILLI-SYNDROME; POSITION-EFFECT VARIEGATION; HISTONE H3 LYSINE-9; FRIEDREICH ATAXIA; DNA METHYLATION; REPEAT EXPANSION; ABERRANT EXPRESSION; IMPRINTING CENTER; MESSENGER-RNA;
D O I：
10.1152/japplphysiol.00053.2010
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Hahn M, Dambacher S, Schotta G. Heterochromatin dysregulation in human diseases. J Appl Physiol 109: 232-242, 2010. First published April 1, 2010; doi: 10.1152/japplphysiol.00053.2010.-Heterochromatin is a repressive chromatin state that is characterized by densely packed DNA and low transcriptional activity. Heterochromatin-induced gene silencing is important for mediating developmental transitions, and in addition, it has more global functions in ensuring chromosome segregation and genomic integrity. Here we discuss how altered heterochromatic states can impair normal gene expression patterns, leading to the development of different diseases. Over the last years, therapeutic strategies that aim toward resetting the epigenetic state of dysregulated genes have been tested. However, due to the complexity of epigenetic gene regulation, the "first-generation drugs" that function globally by inhibiting epigenetic machineries might also introduce severe side effects. Thus detailed understanding of how repressive chromatin states are established and maintained at specific loci will be fundamental for the development of more selective epigenetic treatment strategies in the future.
引用
收藏
页码：232 / 242
页数：11
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