C-reactive protein and statins: IL-8 as a molecular link?

被引：5
作者：
Szmitko, PE
Verma, S
机构：
[1] St Michaels Hosp, Div Cardiac Surg, Toronto, ON M5B 1W8, Canada
[2] Univ Toronto, Div Gen Internal Med, Toronto, ON, Canada
来源：
CLINICAL SCIENCE | 2005年 / 108卷 / 06期
关键词：
atherosclerosis; C-reactive protein (CRP); interleukin-8; mitogen-activated protein kinase (MAPK); 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitor; statin;
D O I：
10.1042/CS20050093
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
CRP (C-reactive protein) has not only emerged as a useful biomarker for cardiovascular disease, but also as a mediator of atherosclerosis. CRP directly activates vascular endothelial cells, amplifying the inflammatory response underlying atherogenesis. The expression of IL (interleukin)-8 appears to serve as one of the downstream effects of CRP. Kibayashi and co-workers in this issue of Clinical Science confirm that CRP induces IL-8 production in human aortic endothelial cells in vitro, via the activation of MAPKs (mitogen-activated protein kinases), an effect that can be inhibited by pitavastatin.
引用
收藏
页码：493 / 495
页数：3
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