Limbic activation to cigarette smoking cues independent of nicotine withdrawal: A perfusion fMRI study

被引:260
作者
Franklin, Teresa R.
wang, Ze
Wang, Jiongjiong
Sciortino, Nathan
Harper, Derek
Li, Yin
Ehrman, Ron
Kampman, Kyle
O'Brien, Charles P.
Detre, John A.
Childress, Anna Rose
机构
[1] Univ Penn, Dept Psychiat, Addict Treatment Res Ctr, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA
[4] Univ Penn, Philadelphia VA Med Ctr, Philadelphia, PA 19104 USA
关键词
cigarette smoking; craving; neuroimaging; ventral striatum; amygdala; DLPFC;
D O I
10.1038/sj.npp.1301371
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Exposure to cigarette smoking cues can trigger physiological arousal and desire to smoke. The brain substrates of smoking cue-induced craving (CIC) are beginning to be elucidated; however, it has been difficult to study this state independent of the potential contributions of pharmacological withdrawal from nicotine. Pharmacological withdrawal itself may have substantial effects on brain activation to cues, either by obscuring or enhancing it, and as CIC is not reduced by nicotine replacement strategies, its neuro-anatomical substrates may differ. Thus, characterizing CIC is critical for developing effective interventions. This study used arterial spin-labeled (ASL) perfusion fMRI, and newly developed and highly appetitive, explicit smoking stimuli, to examine neural activity to cigarette CIC in an original experimental design that strongly minimizes contributions from pharmacological withdrawal. Twenty-one smokers ( 12 females) completed smoking and nonsmoking cue fMRI sessions. Craving self-reports were collected before and after each session. SPM2 software was employed to analyze data. Blood flow ( perfusion) in a priori-selected regions was greater during exposure to smoking stimuli compared to nonsmoking stimuli (p < 0.01; corrected) in ventral striatum, amygdala, orbitofrontal cortex, hippocampus, medial thalamus, and left insula. Perfusion positively correlated with intensity of cigarette CIC in both the dorsolateral prefrontal cortex (r(2) = 0.54) and posterior cingulate (r(2) = 0.53). This pattern of activation that includes the ventral striatum, a critical reward substrate, and the interconnected amygdala, cingulate and OFC, is consistent with decades of animal research on the neural correlates of conditioned drug reward.
引用
收藏
页码:2301 / 2309
页数:9
相关论文
共 45 条
  • [1] REACTIVITY TO SMOKING CUES AND RELAPSE - 2 STUDIES OF DISCRIMINANT VALIDITY
    ABRAMS, DB
    MONTI, PM
    CAREY, KB
    PINTO, RP
    JACOBUS, SI
    [J]. BEHAVIOUR RESEARCH AND THERAPY, 1988, 26 (03) : 225 - 233
  • [2] Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow
    Alsop, DC
    Detre, JA
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1996, 16 (06) : 1236 - 1249
  • [3] [Anonymous], 1994, AM PSYCH ASS DIAGN S
  • [4] Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions
    Bechara, A
    Tranel, D
    Damasio, H
    [J]. BRAIN, 2000, 123 : 2189 - 2202
  • [5] Brain metabolic changes during cigarette craving
    Brody, AL
    Mandelkern, MA
    London, ED
    Childress, AR
    Lee, GS
    Bota, RG
    Ho, ML
    Saxena, S
    Baxter, LR
    Madsen, D
    Jarvik, ME
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 2002, 59 (12) : 1162 - 1172
  • [6] The cue-availability paradigm: The effects of cigarette availability on cue reactivity in smokers
    Carter, BL
    Tiffany, ST
    [J]. EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 2001, 9 (02) : 183 - 190
  • [7] Limbic activation during cue-induced cocaine craving
    Childress, AR
    Mozley, PD
    McElgin, W
    Fitzgerald, J
    Reivich, M
    O'Brien, CP
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 1999, 156 (01) : 11 - 18
  • [8] SELF-ADMINISTERED NICOTINE ACTIVATES THE MESOLIMBIC DOPAMINE SYSTEM THROUGH THE VENTRAL TEGMENTAL AREA
    CORRIGALL, WA
    COEN, KM
    ADAMSON, KL
    [J]. BRAIN RESEARCH, 1994, 653 (1-2) : 278 - 284
  • [9] Ventral striatum/nucleus accumbens activation to smoking-related pictorial cues in smokers and nonsmokers:: A functional magnetic resonance imaging study
    David, SP
    Munafò, MR
    Johansen-Berg, H
    Smith, SM
    Rogers, RD
    Matthews, PM
    Walton, RT
    [J]. BIOLOGICAL PSYCHIATRY, 2005, 58 (06) : 488 - 494
  • [10] PERFUSION IMAGING
    DETRE, JA
    LEIGH, JS
    WILLIAMS, DS
    KORETSKY, AP
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1992, 23 (01) : 37 - 45