Erectile Dysfunction and Later Cardiovascular Disease in Men With Type 2 Diabetes

被引：79

作者：

Batty, G. David ^{[1
,2
,3
]}

Li, Qiang ^{[3
]}

Czernichow, Sebastien ^{[3
,4
]}

Neal, Bruce ^{[3
]}

Zoungas, Sophia ^{[3
,5
]}

Huxley, Rachel ^{[3
]}

Patel, Anushka ^{[3
]}

de Galan, Bastiaan E. ^{[3
,6
]}

Woodward, Mark ^{[3
,7
]}

Hamet, Pavel ^{[8
]}

Harrap, Stephen B. ^{[9
]}

Poulter, Neil ^{[10
,11
]}

Chalmers, John ^{[3
]}

机构：

[1] UCL Epidemiol & Publ Hlth, London WC1E 6BT, England

[2] MRC, Social & Publ Hlth Sci Unit, Glasgow, Lanark, Scotland

[3] George Inst Int Hlth, Sydney, NSW, Australia

[4] Univ Paris 13, Dept Publ Hlth, Avicenne Hosp, Bobigny, France

[5] Monash Univ, Sch Publ Hlth, Melbourne, Vic 3004, Australia

[6] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[7] Mt Sinai Sch Med, New York, NY USA

[8] Ctr Hosp Univ Montreal, Res Ctr, Montreal, PQ, Canada

[9] Univ Melbourne, Dept Physiol, Melbourne, Vic, Australia

[10] Univ London Imperial Coll Sci Technol & Med, London, England

[11] St Marys Hosp, London, England

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2010年 / 56卷 / 23期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国经济与社会研究理事会; 英国工程与自然科学研究理事会;

关键词：

coronary heart disease; epidemiology; erectile dysfunction; stroke; HEART-DISEASE; RISK-FACTORS; POPULATION; PREVALENCE; PREDICTOR;

D O I：

10.1016/j.jacc.2010.04.067

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives The aim of this study was to examine the relationship between erectile problems in men and cardiovascular disease (CVD) mortality. Background Although there are plausible mechanisms linking erectile dysfunction (ED) with coronary heart disease (CHD) and stroke, studies are scarce. Methods In a cohort analysis of the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation) trial population, 6,304 men age 55 to 88 years with type 2 diabetes participated in a baseline medical examination when inquiries were made about ED. Over 5 years of follow-up, during which study members attended repeat clinical examinations, the presence of fatal and nonfatal CVD outcomes, cognitive decline, and dementia was ascertained. Results After adjusting for a range of covariates, including existing illness, psychological health, and classic CVD risk factors, relative to those who were free of the condition, baseline ED was associated with an elevated risk of all CVD events (hazard ratio: 1.19; 95% confidence interval: 1.08 to 1.32), CHD (hazard ratio: 1.35; 95% confidence interval: 1.16 to 1.56), and cerebrovascular disease (hazard ratio: 1.36; 95% confidence interval: 1.11 to 1.67). Men who experienced ED at baseline and at 2-year follow-up had the highest risk for these outcomes. Conclusions In this cohort of men with type 2 diabetes, ED was associated with a range of CVD events. (J Am Coll Cardiol 2010;56:1908-13) (C) 2010 by the American College of Cardiology Foundation

引用

页码：1908 / 1913

页数：6

共 21 条

[1]

Chalmers J, 2001, DIABETOLOGIA, V44, P1118

[2] Male erectile dysfunction and cardiovascular disease: Is there an intimate nexus? [J].