Long-term Effect of Biomineralized Insulin Nanoparticles on Type 2 Diabetes Treatment

被引:13
作者
Xiao, Yun [1 ,3 ]
Wang, Xiaoyu [2 ]
Wang, Ben [3 ]
Liu, Xueyao [1 ]
Xu, Xurong [2 ]
Tang, Ruikang [1 ,2 ]
机构
[1] Zhejiang Univ, Dept Chem, Ctr Biomat & Biopathways, Hangzhou 310027, Zhejiang, Peoples R China
[2] Zhejiang Univ, Qiushi Acad Adv Studies, Hangzhou 310027, Zhejiang, Peoples R China
[3] Zhejiang Univ, Inst Translat Med, Hangzhou 310027, Zhejiang, Peoples R China
来源
THERANOSTICS | 2017年 / 7卷 / 17期
基金
中国国家自然科学基金;
关键词
type; 2; diabetes; biomineralization; insulin; intracellular delivery; CALCIUM-PHOSPHATE NANOPARTICLES; INTRACELLULAR INSULIN; MATERIALS SCIENCE; GENE DELIVERY; PROTEIN; GLUCOSE; RESISTANCE; DRUG; TRANSPORTERS; MECHANISMS;
D O I
10.7150/thno.21450
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Intracellular insulin may exhibit a long-term effect in regulating protein synthesis, DNA synthesis, and gene transcription. However, the intracellular delivery of insulin is a great challenge. Here, we describe how a simple biomineralization modification of insulin can transport it into intact cells on a large scale, leading to a long-term therapeutic effect on diabetes mellitus. Using insulin-resistant HepG2 cell and diabetic KKAy mice as models, in vitro and in vivo assessments have demonstrated that biomineralized insulin nanoparticles can trigger glucose metabolism, and this improvement extends after the treatment. The potential exists to improve the current treatment of type 2 diabetes mellitus through biomineralized modifications of insulin. This study provides a new paradigm of biomimetic nanotechnology for biomedical applications.
引用
收藏
页码:4301 / 4312
页数:12
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