Synthesis, characterization and cytotoxicity studies of chitosan-coated tea polyphenols nanoparticles

被引：97
|
作者：
Liang, Jin [2 ]
Li, Feng [2 ]
Fang, Yong [1 ,2 ]
Yang, Wenjian [2 ]
An, Xinxin [2 ]
Zhao, Liyan [2 ]
Xin, Zhihong [2 ]
Cao, Lin [2 ]
Hu, Qiuhui [1 ]
机构：
[1] Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Nanjing 210046, Peoples R China
[2] Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2011年 / 82卷 / 02期
基金：
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词：
Tea polyphenols; Carboxymethyl chitosan; Chitosan hydrochloride; Nanoparticles; Cytotoxicity; CARBOXYMETHYL CHITOSAN; DELIVERY; BIOAVAILABILITY; DRUG;
D O I：
10.1016/j.colsurfb.2010.08.045
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Chitosan nanoparticles (CS-NPs) were prepared by ionic gelation method using carboxymethyl chitosan and chitosan hydrochloride as carriers of tea polyphenols. The characteristics of chitosan-coated tea polyphenols nanoparticles (CS-TP NPs) were determined by using transmission electron microscopy (TEM) and FT-IR spectroscopy. It was found that the synthesized CS-TP NPs were non-spherical in shape with an average size of 407 +/- 50 nm. Meanwhile, the drug content and encapsulation rate of the nanoparticles was 8-16% and 44-83%, respectively. These CS-TP NPs also demonstrated sustained release of tea polyphenols in PBS. The antitumor of CS-TP NPs towards HepG2 cancer cells was investigated. The result showed that CS-TP NPs retained significant antitumor activities. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：297 / 301
页数：5
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