Brain functional alterations in Type 2 Diabetes - A systematic review of fMRI studies

被引：86
作者：
Macpherson, Helen [1 ]
Formica, Melissa [1 ]
Harris, Elizabeth [2 ]
Daly, Robin M. [1 ]
机构：
[1] Deakin Univ, Inst Phys Act & Nutr, Geelong, Vic, Australia
[2] Swinburne Univ, Ctr Human Psychopharmacol, Hawthorn, Vic, Australia
来源：
FRONTIERS IN NEUROENDOCRINOLOGY | 2017年 / 47卷
关键词：
Type; 2; Diabetes; Brain; Cognition; Functional magnetic resonance imaging (fMRI); Default mode network; WHITE-MATTER ABNORMALITIES; MILD COGNITIVE IMPAIRMENT; DEFAULT-MODE NETWORK; VASCULAR DEMENTIA; ALZHEIMERS-DISEASE; RISK-FACTOR; CONNECTIVITY; MEMORY; MRI; DYSFUNCTION;
D O I：
10.1016/j.yfrne.2017.07.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Type 2 Diabetes (T2DM) is emerging as a major global health issue. T2DM can adversely affect cognition and increase dementia risk. This systematic review aimed to examine the functional brain changes that may underlie cognitive dysfunction in adults with T2DM. Studies were restricted to those which used functional magnetic resonance imaging (fMRI). Nineteen independent studies were identified, mostly comprised of middle aged or older adults. Resting-state studies demonstrated that compared to controls, connectivity of the Default Mode Network (DMN) was reduced and the majority of task-based studies identified reduced activation in T2DM patients in regions relevant to task performance. Abnormalities of low frequency spontaneous brain activity were observed, particularly in visual regions. As most studies demonstrated that alterations in fMRI were related to poorer neurppsychological task performance, these results indicate that functional brain abnormalities in T2DM have consequences for cognition.
引用
收藏
页码：34 / 46
页数：13
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