Redefining thalassemia as a hypercoagulable state

被引：74

作者：

Cappellini, M. Domenica ^{[1
]}

Motta, Irene ^{[1
]}

Musallam, Khaled M. ^{[2
]}

Taher, Ali T. ^{[2
]}

机构：

[1] Univ Milan, Fdn Osped Maggiore Policlin Mangiagalli Regina El, Milan, Italy

[2] American Univ, Beirut Med Ctr, Div Hematol Oncol, Dept Internal Med, Beirut, Lebanon

来源：

COOLEY'S ANEMIA: NINTH SYMPOSIUM | 2010年 / 1202卷

关键词：

thalassemia; hypercoagulability; thromboembolism; stroke; VIVO PLATELET ACTIVATION; RED-BLOOD-CELLS; BETA-THALASSEMIA; THROMBOEMBOLIC EVENTS; INTERMEDIA; COMPLICATIONS; SURVIVAL; PHOSPHATIDYLSERINE; EXPOSURE; IRON;

D O I：

10.1111/j.1749-6632.2010.05548.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

As the life expectancy of beta-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed.

引用

页码：231 / 236

页数：6

共 45 条

[1]

[Anonymous], 2001, THALASSAEMIA SYNDROM

[2] β-thalassaemia and sickle cell anaemia as paradigms of hypercoagulability [J].