Polar Alkaloids from the Caribbean Marine Sponge Niphates digitalis

被引：0

作者：

Regalado, Erik L. ^{[1
]}

Mendiola, Judith ^{[2
]}

Laguna, Abilio ^{[1
]}

Nogueiras, Clara ^{[3
]}

Thomas, Olivier P. ^{[4
]}

机构：

[1] Ctr Marine Bioprod CEB1MAR, Dept Chem, Havana 10400, Cuba

[2] Inst Trop Med Pedro Kouri IPK, Dept Parasitol, Havana, Cuba

[3] Univ Havana, Ctr Nat Prod, Fac Chem, Havana 10400, Cuba

[4] Univ Nice Sophia Antipolis, Lab Chim Mol Bioact & Aromes, CNRS,Inst Chim Nice, Fac Sci,UMR 6001, F-06108 Nice, France

来源：

NATURAL PRODUCT COMMUNICATIONS | 2010年 / 5卷 / 08期

关键词：

Marine sponge; Niphates digitalis; nucleosides; nucleobases; antimalarial activity; cytotoxicity; MALARIA PARASITES; NUCLEOSIDES; METABOLITES; PRODUCTS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A method involving flash chromatography, semi-preparative phenylhexyl RP HPLC-DAD-ELSD combined with analytic polar-RP HPLC-DAD, was applied to separate and purify six highly nitrogenated bases and a bicyclic amidine alkaloid, the major components of the marine sponge Niphates digitalis. Their structures were identified as 1,8-diazabicyclo[5.4.0]undec-7-ene (1), deoxycytidine (2), phenylalanine (3), adenosine (4), deoxyguanosine (5), adenine (6) and thymidine (7) on the basis of spectroscopic data analyses. This is the first report of these compounds in a marine sponge belonging to the Niphates genus and the first evidence of the presence of 1 from a natural source.

引用

页码：1187 / 1190

页数：4

共 35 条

[31] ISOLATION OF SPONGOSINE AND 2'-DEOXYSPONGOSINE FROM A WESTERN-AUSTRALIAN SPONGE OF THE ORDER HADROMERIDA (TETHYIDAE) [J].

SEARLE, PA ;

MOLINSKI, TF .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (10) :1452-1454

[32] TRACHYCLADINE-A AND TRACHYCLADINE-B - 2'-C-METHYL-5'-DEOXYRIBOFURANOSYL NUCLEOSIDES FROM THE MARINE SPONGE TRACHYCLADUS LAEVISPIRULIFER [J].

SEARLE, PA ;

MOLINSKI, TF .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (13) :4296-4298

[33] AN IMPROVED MTT ASSAY [J].

SLADOWSKI, D ;

STEER, SJ ;

CLOTHIER, RH ;

BALLS, M .

JOURNAL OF IMMUNOLOGICAL METHODS, 1993, 157 (1-2) :203-207

[34]

SWEETMAN SC, 2000, COMPLETE DRUG REFERE, P484

[35] NIPHATOXIN-A AND NIPHATOXIN-B - 2 NEW ICHTHYOTOXIC AND CYTOTOXIC TRIPYRIDINE ALKALOIDS FROM A MARINE SPONGE [J].

TALPIR, R ;

RUDI, A ;

ILAN, M ;

KASHMAN, Y .

TETRAHEDRON LETTERS, 1992, 33 (21) :3033-3034

← 1 2 3 4 →