Mechanisms of Lung Fibrosis Resolution

被引:105
作者
Glasser, Stephan W. [1 ]
Hagood, James S. [3 ,5 ]
Wong, Simon [3 ]
Taype, Carmen A. [4 ]
Madala, Satish K. [2 ]
Hardie, William D. [2 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Div Pulm Biol, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Hosp Med Ctr, Dept Pulm Med, 3333 Burnet Ave, Cincinnati, OH 45229 USA
[3] Univ Calif San Diego, Div Pediat Resp Med, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Div Pulm Crit Care & Sleep Med, La Jolla, CA 92093 USA
[5] Rady Childrens Hosp San Diego, Div Resp Med, San Diego, CA USA
关键词
RESPIRATORY-DISTRESS-SYNDROME; PULMONARY-FIBROSIS; CELLULAR SENESCENCE; MYOFIBROBLAST DIFFERENTIATION; MATRIX METALLOPROTEINASES; HISTONE MODIFICATIONS; APOPTOSIS RESISTANCE; FIBROBLAST APOPTOSIS; PROSTAGLANDIN E-2; RAT LUNG;
D O I
10.1016/j.ajpath.2016.01.018
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Fibrogenesis involves a dynamic interplay between factors that promote the biosynthesis and deposition of extracellular matrix along with pathways that degrade the extracellular matrix and eliminate the primary effector cells. Opposing the often held perception that fibrotic tissue is permanent, animal studies and clinical data now demonstrate the highly plastic nature of organ fibrosis that can, under certain circumstances, regress. This review describes the current understanding of the mechanisms whereby the lung is known to resolve fibrosis focusing on degradation of the extracellular matrix, removal of myofibroblasts, and the role of inflammatory cells. Although there are significant gaps in understanding Lung fibrosis resolution, accelerated improvements in biotechnology and bioinformatics are expected to improve the understanding of these mechanisms and have high potential to lead to novel and effective restorative therapies in the treatment not only of pulmonary fibrosis, but also of a wide-ranging spectrum of chronic disorders.
引用
收藏
页码:1066 / 1077
页数:12
相关论文
共 100 条
[1]   X-Linked Inhibitor of Apoptosis Regulates Lung Fibroblast Resistance to Fas-Mediated Apoptosis [J].
Ajayi, Iyabode O. ;
Sisson, Thomas H. ;
Higgins, Peter D. R. ;
Booth, Adam J. ;
Sagana, Rommel L. ;
Huang, Steven K. ;
White, Eric S. ;
King, Jessie E. ;
Moore, Bethany B. ;
Horowitz, Jeffrey C. .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2013, 49 (01) :86-95
[2]   CONNECTIVE-TISSUE OF RAT LUNG .2. ULTRASTRUCTURAL-LOCALIZATION OF COLLAGEN TYPE-III, TYPE-IV AND TYPE-VI [J].
AMENTA, PS ;
GIL, J ;
MARTINEZHERNANDEZ, A .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1988, 36 (09) :1167-1173
[3]   The role of TIMPs in regulation of extracellular matrix proteolysis [J].
Arpino, Valerie ;
Brock, Michael ;
Gill, Sean E. .
MATRIX BIOLOGY, 2015, 44-46 :247-254
[4]   Nuclear Factor Erythroid 2-Related Factor 2 Nuclear Translocation Induces Myofibroblastic Dedifferentiation in Idiopathic Pulmonary Fibrosis [J].
Artaud-Macari, Elise ;
Goven, Delphine ;
Brayer, Stephanie ;
Hamimi, Akila ;
Besnard, Valerie ;
Marchal-Somme, Joelle ;
El Ali, Zeina ;
Crestani, Bruno ;
Kerdine-Roemer, Saadia ;
Boutten, Anne ;
Bonay, Marcel .
ANTIOXIDANTS & REDOX SIGNALING, 2013, 18 (01) :66-79
[5]   Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-Induced Lung Fibrosis [J].
Ashley, Shanna L. ;
Sisson, Thomas H. ;
Wheaton, Amanda K. ;
Kim, Kevin K. ;
Wilke, Carol A. ;
Ajayi, Iyabode O. ;
Subbotina, Natalya ;
Wang, Shaomeng ;
Duckett, Colin S. ;
Moore, Bethany B. ;
Horowitz, Jeffrey C. .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2016, 54 (04) :482-492
[6]   Mfge8 is critical for mammary gland remodeling during involution [J].
Atabai, K ;
Fernandez, R ;
Huang, XZ ;
Ueki, I ;
Kline, A ;
Li, Y ;
Sadatmansoori, S ;
Smith-Steinhart, C ;
Zhu, WM ;
Pytela, R ;
Werb, Z ;
Sheppard, D .
MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (12) :5528-5537
[7]   Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages [J].
Atabai, Kamran ;
Jame, Sina ;
Azhar, Nabil ;
Kuo, Alex ;
Lam, Michael ;
McKleroy, William ;
DeHart, Greg ;
Rahman, Salman ;
Xia, Dee Dee ;
Melton, Andrew C. ;
Wolters, Paul ;
Emson, Claire L. ;
Turner, Scott M. ;
Werb, Zena ;
Sheppard, Dean .
JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (12) :3713-3722
[8]   Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders [J].
Baker, Darren J. ;
Wijshake, Tobias ;
Tchkonia, Tamar ;
LeBrasseur, Nathan K. ;
Childs, Bennett G. ;
van de Sluis, Bart ;
Kirkland, James L. ;
van Deursen, Jan M. .
NATURE, 2011, 479 (7372) :232-U112
[9]   Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment [J].
Barry-Hamilton, Vivian ;
Spangler, Rhyannon ;
Marshall, Derek ;
McCauley, Scott ;
Rodriguez, Hector M. ;
Oyasu, Miho ;
Mikels, Amanda ;
Vaysberg, Maria ;
Ghermazien, Haben ;
Wai, Carol ;
Garcia, Carlos A. ;
Velayo, Arleene C. ;
Jorgensen, Brett ;
Biermann, Donna ;
Tsai, Daniel ;
Green, Jennifer ;
Zaffryar-Eilot, Shelly ;
Holzer, Alison ;
Ogg, Scott ;
Thai, Dung ;
Neufeld, Gera ;
Van Vlasselaer, Peter ;
Smith, Victoria .
NATURE MEDICINE, 2010, 16 (09) :1009-U107
[10]   IMMUNOHISTOCHEMICAL STUDY OF COLLAGEN TYPES IN HUMAN-FETAL LUNG AND FIBROTIC LUNG-DISEASE [J].
BATEMAN, E ;
TURNERWARWICK, M ;
ADELMANNGRILL, BC .
THORAX, 1981, 36 (09) :645-653