Activation and repression in the nervous system

被引：14
作者：
Goodman, RH
Mandel, G
机构：
[1] Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97201 USA
[2] SUNY Stony Brook, Dept Neurobiol & Behav, Howard Hughes Med Inst, Stony Brook, NY 11794 USA
来源：
CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 03期
关键词：
D O I：
10.1016/S0959-4388(98)80069-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The mechanisms underlying transcriptional activation and repression have become much clearer. Recent evidence suggests that transcription factors that do not bind DNA directly, the co-activators and co-repressors, mediate a large number of cell signaling events. Their association with histone acetylases, to mediate activation, or deacetylases, to mediate repression, provide a model for explaining how gene expression is regulated.
引用
收藏
页码：413 / 417
页数：5
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