Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress

被引：27

作者：

Dalla Sega, Francesco Vieceli ^{[1
]}

Aquila, Giorgio ^{[1
]}

Fortini, Francesca ^{[1
]}

Vaccarezza, Mauro ^{[2
]}

Secchiero, Paola ^{[3
,4
]}

Rizzo, Paola ^{[3
,5
]}

Campo, Gianluca ^{[1
,6
]}

机构：

[1] Univ Ferrara, Dept Med Sci, Ferrara, Italy

[2] Curtin Univ, Sch Biomed Sci, Fac Hlth Sci, Perth, WA, Australia

[3] Univ Ferrara, Dept Morphol Surg & Expt Med, Ferrara, Italy

[4] Lab Technol Adv Therapies LTTA Ctr, Ferrara, Italy

[5] ES Hlth Sci Fdn, Maria Cecilia Hosp, GVM Care & Res, Cotignola, RA, Italy

[6] Azienda Osped Univ S Anna, Cardiovasc Inst, Cona, FE, Italy

来源：

BIOFACTORS | 2017年 / 43卷 / 04期

关键词：

ROS; Notch; shear stress; endothelial dysfunction; OXYGEN SPECIES PRODUCTION; NADPH OXIDASE; OXIDATIVE STRESS; HYDROGEN-PEROXIDE; XANTHINE-OXIDASE; ATHEROSCLEROTIC LESIONS; DIFFERENTIAL ROLES; ANGIOTENSIN-II; BLOOD-PRESSURE; FLOW PATTERNS;

D O I：

10.1002/biof.1359

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species (ROS) act as signal molecules in several biological processes whereas excessive, unregulated, ROS production contributes to the development of pathological conditions including endothelial dysfunction and atherosclerosis. The maintenance of a healthy endothelium depends on many factors and on their reciprocal interactions; in this framework, the Notch pathway and shear stress (SS) play two lead roles. Recently, evidence of a crosstalk between ROS, Notch, and SS, is emerging. The aim of this review is to describe the way ROS interact with the Notch pathway and SS protecting fromor promotingthe development of endothelial dysfunction. (c) 2017 BioFactors, 43(4):475-485, 2017

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收藏

页码：475 / 485

页数：11

相关论文

共 115 条

[11] The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell Phenotype [J].

Brandes, Ralf P. ;

Harenkamp, Sabine ;

Schuermann, Christoph ;

Josipovic, Ivana ;

Rashid, Beliza ;

Rezende, Flavia ;

Loewe, Oliver ;

Moll, Franziska ;

Epah, Jeremy ;

Eresch, Jeanette ;

Nayak, Arnab ;

Kopaliani, Irakli ;

Penski, Cornelia ;

Mittelbronn, Michel ;

Weissmann, Norbert ;

Schroeder, Katrin .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2016, 36 (08) :1558-1565

[12] Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress [J].

Breton-Romero, Rosa ;

Gonzalez de Orduna, Cecilia ;

Romero, Natalia ;

Sanchez-Gomez, Francisco J. ;

de Alvaro, Cristina ;

Porras, Almudena ;

Rodriguez-Pascual, Fernando ;

Laranjinha, Joao ;

Radi, Rafael ;

Lamas, Santiago .

FREE RADICAL BIOLOGY AND MEDICINE, 2012, 52 (06) :1093-1100

[13] Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis [J].

Briot, Anais ;

Civelek, Mete ;

Seki, Atsuko ;

Hoi, Karen ;

Mack, Julia J. ;

Lee, Stephen D. ;

Kim, Jason ;

Hong, Cynthia ;

Yu, Jingjing ;

Fishbein, Gregory A. ;

Vakili, Ladan ;

Fogelman, Alan M. ;

Fishbein, Michael C. ;

Lusis, Aldons J. ;

Tontonoz, Peter ;

Navab, Mohamad ;

Berliner, Judith A. ;

Iruela-Arispe, M. Luisa .

JOURNAL OF EXPERIMENTAL MEDICINE, 2015, 212 (12) :2147-2163

[14] Inhibition of Notch signaling leads to increased intracellular ROS by up-regulating Nox4 expression in primary HUVECs [J].

Cai, Wei-Xia ;

Liang, Liang ;

Wang, Li ;

Han, Jun-Tao ;

Zhu, Xiong-Xiang ;

Han, Hua ;

Hu, Da-Hai ;

Zhang, Ping .

CELLULAR IMMUNOLOGY, 2014, 287 (02) :129-135

[15] 17β-Estradiol Enhances Signalling Mediated by VEGF-A-Delta-Like Ligand 4-Notch1 Axis in Human Endothelial Cells [J].

Caliceti, Cristiana ;

Aquila, Giorgio ;

Pannella, Micaela ;

Morelli, Marco Bruno ;

Fortini, Cinzia ;

Pinton, Paolo ;

Bonora, Massimo ;

Hrelia, Silvana ;

Pannuti, Antonio ;

Miele, Lucio ;

Rizzo, Paola ;

Ferrari, Roberto .

PLOS ONE, 2013, 8 (08)

[16] Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress - An intravascular ultrasound and histopathology natural history study [J].

Chatzizisis, Yiannis S. ;

Jonas, Michael ;

Coskun, Ahmet U. ;

Beigel, Roy ;

Stone, Benjamin V. ;

Maynard, Charles ;

Gerrity, Ross G. ;

Daley, William ;

Rogers, Campbell ;

Edelman, Elazer R. ;

Feldman, Charles L. ;

Stone, Peter H. .

CIRCULATION, 2008, 117 (08) :993-1002

[17] Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling - Molecular, cellular, and vascular behavior [J].

Chatzizisis, Yiannis S. ;

Coskun, Ahmet Umit ;

Jonas, Michael ;

Edelman, Elazer R. ;

Feldman, Charles L. ;

Stone, Peter H. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (25) :2379-2393

[18] Force-Induced Unfolding Simulations of the Human Notch1 Negative Regulatory Region: Possible Roles of the Heterodimerization Domain in Mechanosensing [J].

Chen, Jianhan ;

Zolkiewska, Anna .

PLOS ONE, 2011, 6 (07)

[19] NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation [J].

Craige, Siobhan M. ;

Chen, Kai ;

Pei, Yongmei ;

Li, Chunying ;

Huang, Xiaoyun ;

Chen, Christine ;

Shibata, Rei ;

Sato, Kaori ;

Walsh, Kenneth ;

Keaney, John F., Jr. .

CIRCULATION, 2011, 124 (06) :731-U193

[20] The role of shear stress in the pathogenesis of atherosclerosis [J].

Cunningham, KS ;

Gotlieb, AI .

LABORATORY INVESTIGATION, 2005, 85 (01) :9-23

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