Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress

被引：27

作者：

Dalla Sega, Francesco Vieceli ^{[1
]}

Aquila, Giorgio ^{[1
]}

Fortini, Francesca ^{[1
]}

Vaccarezza, Mauro ^{[2
]}

Secchiero, Paola ^{[3
,4
]}

Rizzo, Paola ^{[3
,5
]}

Campo, Gianluca ^{[1
,6
]}

机构：

[1] Univ Ferrara, Dept Med Sci, Ferrara, Italy

[2] Curtin Univ, Sch Biomed Sci, Fac Hlth Sci, Perth, WA, Australia

[3] Univ Ferrara, Dept Morphol Surg & Expt Med, Ferrara, Italy

[4] Lab Technol Adv Therapies LTTA Ctr, Ferrara, Italy

[5] ES Hlth Sci Fdn, Maria Cecilia Hosp, GVM Care & Res, Cotignola, RA, Italy

[6] Azienda Osped Univ S Anna, Cardiovasc Inst, Cona, FE, Italy

来源：

BIOFACTORS | 2017年 / 43卷 / 04期

关键词：

ROS; Notch; shear stress; endothelial dysfunction; OXYGEN SPECIES PRODUCTION; NADPH OXIDASE; OXIDATIVE STRESS; HYDROGEN-PEROXIDE; XANTHINE-OXIDASE; ATHEROSCLEROTIC LESIONS; DIFFERENTIAL ROLES; ANGIOTENSIN-II; BLOOD-PRESSURE; FLOW PATTERNS;

D O I：

10.1002/biof.1359

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species (ROS) act as signal molecules in several biological processes whereas excessive, unregulated, ROS production contributes to the development of pathological conditions including endothelial dysfunction and atherosclerosis. The maintenance of a healthy endothelium depends on many factors and on their reciprocal interactions; in this framework, the Notch pathway and shear stress (SS) play two lead roles. Recently, evidence of a crosstalk between ROS, Notch, and SS, is emerging. The aim of this review is to describe the way ROS interact with the Notch pathway and SS protecting fromor promotingthe development of endothelial dysfunction. (c) 2017 BioFactors, 43(4):475-485, 2017

引用

页码：475 / 485

页数：11

共 115 条

[1] Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase [J].