γ-Mangostin Ameliorates Free Fatty Acid-Induced Lipid Accumulation via the SIRT1/LKB1/AMPK Pathway in HepG2 and L02 Cells

被引：30

作者：

Gu, Liang ^{[1
]}

Cai, Nan ^{[1
,2
]}

Lyu, Yansi ^{[3
]}

Yao, Lijun ^{[1
]}

Wang, Fei ^{[4
]}

Xu, Hong ^{[1
]}

Hu, Zhangli ^{[1
]}

Li, Hui ^{[1
]}

Xu, Xu ^{[1
]}

机构：

[1] Shenzhen Univ, Shenzhen Key Lab Marine Bioresource & Ecoenvironm, Guangdong Prov Key Lab Plant Epigenet,Coll Life S, Coll Optoelect Engn,Minist Educ & Guangdong Prov, Shenzhen 518060, Guangdong, Peoples R China

[2] Shenzhen Univ, Key Lab Optoelect Devices & Syst, Minist Educ & Guangdong Prov, Coll Optoelect Engn, Shenzhen 518060, Guangdong, Peoples R China

[3] Shenzhen Univ, Gen Hosp, Dept Dermatol, Shenzhen 518055, Guangdong, Peoples R China

[4] Shenzhen Univ, Gen Hosp, Dept Spine Surg, Shenzhen 518055, Guangdong, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2019年 / 67卷 / 50期

基金：

中国国家自然科学基金;

关键词：

the AMPK pathway; Compound C; alpha-mangostin; gamma-mangostin; nonalcoholic fatty liver disease (NAFLD); ACTIVATED PROTEIN-KINASE; LIVER-DISEASE; GARCINIA-MANGOSTANA; ALPHA-MANGOSTIN; METABOLISM; STEATOSIS; ENERGY; ROLES; LKB1;

D O I：

10.1021/acs.jafc.9b05632

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Lipid accumulation is a typical characteristic of nonalcoholic fatty liver disease (NAFLD). The inhibition of lipid accumulation is regarded as a potential treatment for NAFLD. In this study, we investigated the effects of gamma-mangostin or alpha-mangostin on lipid accumulation in a cell model. Analysis of the inhibitory effects of gamma-mangostin on lipid accumulation revealed that it downregulated NAFLD-related biochemical parameters and stimulated the SIRT1/LKB1/AMPK pathway. Consequently, it suppressed lipid synthesis and enhanced fatty acid oxidation. Moreover, we demonstrated that the blockage of AMP-activated protein kinase (AMPK) by the pharmacological inhibitor Compound C abrogated the promoting effect of AMPK. Similar results were also observed for alpha-mangostin. The effects of alpha-mangostin on lipid accumulation were inferior to those of gamma-mangostin. The differences in CPT1A activity might be originated from their different chemical structures. Our results suggested that gamma-mangostin and alpha-mangostin can be exploited as potential candidates for NAFLD treatment.

引用

页码：13929 / 13938

页数：10

共 33 条

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