Diverse mechanisms and machineries for import of mitochondrial proteins

被引：20

作者：

Milenkovic, Dusanka ^{[1
]}

Mueller, Judith ^{[1
]}

Stojanovski, Diana ^{[1
]}

Pfanner, Nikolaus ^{[1
]}

Chacinska, Agnieszka ^{[1
]}

机构：

[1] Univ Freiburg, Zentrum Biochem & Mol Zellforsch, Inst Biochem & Mol Biol, D-79104 Freiburg, Germany

来源：

BIOLOGICAL CHEMISTRY | 2007年 / 388卷 / 09期

关键词：

complex assembly; disulfide bonds; mitochondria; protein import; protein sorting; translocase;

D O I：

10.1515/BC.2007.097

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are ubiquitous organelles; that play an essential role in energy conversion and biosynthetic pathways in eukaryotic cells. Most mitochondrial proteins must be imported from the cytosol and sorted into one of the four mitochondrial subcompartments, the outer membrane, the intermembrane space, the inner membrane and the matrix. Studies in recent years revealed a remarkable diversity of mechanisms and machineries that are required for the import of proteins into mitochondria. At least four different pathways for the sorting and assembly of nuclear-encoded mitochondrial proteins have been identified.

引用

页码：891 / 897

页数：7

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