The Molecular Pathophysiology of Concussive Brain Injury - an Update

被引：136

作者：

Barkhoudarian, Garni ^{[1
]}

Hovda, David A. ^{[2
,3
]}

Giza, Christopher C. ^{[4
,5
]}

机构：

[1] Providence St Johns Hlth Ctr, John Wayne Canc Inst, Pacific Pituitary Disorders Ctr, 2200 Santa Monica Blvd, Santa Monica, CA 90404 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, UCLA Brain Injury Res Ctr, Dept Neurosurg,Interdept Program Neurosci,Semel I, Room 18-228A,10833 Le Conte Blvd, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, UCLA Brain Injury Res Ctr,Semel Inst, Interdept Program Neurosci,Dept Med & Mol Pharmac, Room 18-228A,10833 Le Conte Blvd, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, UCLA Brain Injury Res Ctr,Semel Inst,Mattel Child, Interdept Programs Neurosci & Biomed Engn,Dept Ne, Room 18-218B,10833 Le Conte Blvd, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, David Geffen Sch Med,Dept Pediat, UCLA Brain Injury Res Ctr,Semel Inst,Mattel Child, Interdept Programs Neurosci & Biomed Engn,Div Ped, Room 18-218B,10833 Le Conte Blvd, Los Angeles, CA 90095 USA

来源：

PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA | 2016年 / 27卷 / 02期

关键词：

Concussion; Traumatic brain injury; Pathophysiology; Molecular mechanisms; CHRONIC TRAUMATIC ENCEPHALOPATHY; FLUID PERCUSSION INJURY; LONG-TERM POTENTIATION; CORTICAL IMPACT INJURY; REPETITIVE HEAD-INJURY; TEMPORAL WINDOW; MITOCHONDRIAL DYSFUNCTION; RECURRENT CONCUSSION; COGNITIVE IMPAIRMENT; GLUCOSE-UTILIZATION;

D O I：

10.1016/j.pmr.2016.01.003

中图分类号：

R49 [康复医学];

学科分类号：

100215 ;

摘要：

Concussion, or mild traumatic brain injury (TBI), affects millions of patients worldwide. Understanding the pathophysiology of TBI can help manage its repercussions. The brain is significantly altered immediately following mild TBI because of metabolic, hemodynamic, structural, and electrophysiologic changes. This process affects cognition and behavior and can leave the brain vulnerable for worse injury in the setting of repeat insult. This article is an update of our previously published review, reporting relevant and current studies from the bench to the bedside of mild TBI. Understanding the pathobiology can help prevent and treat mild TBI.

引用

页码：373 / +

页数：22

共 159 条

[1] Anterior pituitary dysfunction in survivors of traumatic brain injury [J].