Family-based association study between GRIK2 polymorphisms and autism spectrum disorders in the Korean trios

被引：33
作者：
Kim, Soon Ae
Kim, Jin Hee
Park, Mira
Cho, In Hee
Yoo, Hee Jeong
机构：
[1] Seoul Natl Univ Bundang Hosp, Dept Psychiat, Songnam 463707, Kyunggi, South Korea
[2] Eulji Univ, Sch Med, Dept Pharmacol, Taejon, South Korea
[3] Eulji Univ, Sch Med, Div Biostat, Taejon, South Korea
[4] Gachon Med Sch, Dept Neuropsychiat, Inchon, South Korea
来源：
NEUROSCIENCE RESEARCH | 2007年 / 58卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
autism spectrum disorders (ASD); transmission disequilibrium test (TDT); glutamate receptor 6 (GRIK2); association; GLUTAMATE-RECEPTOR-6; GENE; FOLLOW-UP; KAINATE; HIPPOCAMPUS; EPILEPSY; CHILDREN; LINKAGE; GLUR6; AGE;
D O I：
10.1016/j.neures.2007.03.002
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with strong genetic components. The present study comprises the detection of four single nucleotide polymorphisms (SNPs) in GRIK2 followed by a family-based association analysis of the SNPs in 126 Korean ASD trios by using the transmission disequilibrium test (TDT) and haplotype analysis. We found preferential transmission of the C allele at the rs3213607 (P < 0.001) of GRIK2 in ASD and haplotype analysis revealed that one haplotype demonstrated a significant association (P = 0.023). These results suggest a potential association between GRIK2 and ASD in the Korean population, (C) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
引用
收藏
页码：332 / 335
页数：4
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