Preimplantation Genetic Testing for Aneuploidy - a Castle Built on Sand

被引：59
作者：
Gleicher, Norbert [1 ,2 ,3 ,4 ]
Patrizio, Pasquale [1 ,5 ]
Brivanlou, Ali [3 ]
机构：
[1] Ctr Human Reprod CHR, New York, NY 10021 USA
[2] Fdn Reprod Med, New York, NY 10021 USA
[3] Rockefeller Univ, Stem Cell & Embryol Lab, 1230 York Ave, New York, NY 10021 USA
[4] Univ Vienna, Dept Obstet & Gynecol, Sch Med, Vienna, Austria
[5] Yale Univ, Dept Obstet & Gynecol & Reprod Sci, New Haven, CT USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2021年 / 27卷 / 08期
关键词：
IN-VITRO FERTILIZATION; SCREENING PGS; EMBRYOS; MOSAICISM; DIAGNOSIS; BLASTOCYSTS; INSTABILITY; REVEALS; CYCLES; COMMON;
D O I：
10.1016/j.molmed.2020.11.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Preimplantation genetic testing for aneuploidy (PGT-A) has become a routine add-on for in vitro fertilization (IVF) to determine whether human embryos are to be clinically utilized or disposed of. Studies claiming IVF outcome improvements following PGT-A, however, used highly selected patient populations or inappropriate statistical methodologies. PGT-A was never clinically validated in its ability to define a human embryo as chromosomal normal, mosaic, or aneuploid, nor certified by a regulatory body, or an authoritative professional organization. Because of a high false-positive rate, PGT-A, actually reduces live IVF birth chances for many patients. Furthermore, in recent studies the PGT-A hypothesis was demonstrated to be mistaken for biological, mathematical and technical reasons. PGT-A, therefore, should clinically only be offered within experimental study frameworks.
引用
收藏
页码：731 / 742
页数：12
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