Reduced antibody activity against SARS-CoV-2 B.1.617.2 delta virus in serum of mRNA-vaccinated individuals receiving tumor necrosis factor-α inhibitors

被引：37

作者：

Chen, Rita E. ^{[1
,2
]}

Gorman, Matthew J. ^{[3
]}

Zhu, Daniel Y. ^{[4
]}

Carreno, Juan Manuel ^{[5
]}

Yuan, Dansu ^{[3
]}

VanBlargan, Laura A. ^{[1
]}

Burdess, Samantha ^{[1
]}

Lauffenburger, Douglas A. ^{[4
]}

Kim, Wooseob ^{[2
]}

Turner, Jackson S. ^{[2
]}

Droit, Lindsay ^{[2
]}

Handley, Scott A. ^{[2
]}

Chahin, Salim ^{[6
]}

Deepak, Parakkal ^{[1
]}

O'Halloran, Jane A. ^{[1
]}

Paley, Michael A. ^{[1
]}

Presti, Rachel M. ^{[1
,7
,8
]}

Wu, Gregory F. ^{[6
]}

Krammer, Florian ^{[5
]}

Alter, Galit ^{[3
]}

Ellebedy, Ali H. ^{[2
,7
,8
]}

Kim, Alfred H. J. ^{[1
,7
]}

Diamond, Michael S. ^{[1
,2
,7
,8
,9
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA

[3] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA

[4] MIT, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[5] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[6] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[7] Washington Univ, Sch Med, Andrew M & Jane M Bursky Ctr Human Immunol & Imm, St Louis, MO 63130 USA

[8] Washington Univ, Sch Med, Ctr Vaccines & Immun Microbial Pathogens, St Louis, MO 63130 USA

[9] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

来源：

MED | 2021年 / 2卷 / 12期

关键词：

INFLAMMATORY-BOWEL-DISEASE; NEUTRALIZING ANTIBODIES; IMMUNE-RESPONSE; HIGH-THROUGHPUT; INFLUENZA; IMMUNOSUPPRESSION; METHOTREXATE; EVOLUTION; REVEALS; INTACT;

D O I：

10.1016/j.medj.2021.11.004

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: Although vaccines effectively prevent coronavirus disease 2019 (COVID-19) in healthy individuals, they appear to be less immunogenic in individuals with chronic inflammatory disease (CID) or receiving chronic immunosuppression therapy. Methods: Here we assessed a cohort of 77 individuals with CID treated as monotherapy with chronic immunosuppressive drugs for antibody responses in serum against historical and variant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses after immunization with the BNT162b2 mRNA vaccine. Findings: Longitudinal analysis showed the greatest reductions in neutralizing antibodies and Fc effector function capacity in individuals treated with tumor necrosis factor alpha (TNF-alpha) inhibitors (TNFi), and this pattern appeared to be worse against the B.1.617.2 delta virus. Within 5 months of vaccination, serum neutralizing titers of all TNFi-treated individuals tested fell below the presumed threshold correlate for antibody-mediated protection. However, TNFi-treated individuals receiving a third mRNA vaccine dose boosted their serum neutralizing antibody titers by more than 16-fold. Conclusions: Vaccine boosting or administration of long-acting prophylaxis (e.g., monoclonal antibodies) will likely be required to prevent SARS-CoV-2 infection in this susceptible population.

引用

页码：1327 / +

页数：20

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