Reduced antibody activity against SARS-CoV-2 B.1.617.2 delta virus in serum of mRNA-vaccinated individuals receiving tumor necrosis factor-α inhibitors

被引：37

作者：

Chen, Rita E. ^{[1
,2
]}

Gorman, Matthew J. ^{[3
]}

Zhu, Daniel Y. ^{[4
]}

Carreno, Juan Manuel ^{[5
]}

Yuan, Dansu ^{[3
]}

VanBlargan, Laura A. ^{[1
]}

Burdess, Samantha ^{[1
]}

Lauffenburger, Douglas A. ^{[4
]}

Kim, Wooseob ^{[2
]}

Turner, Jackson S. ^{[2
]}

Droit, Lindsay ^{[2
]}

Handley, Scott A. ^{[2
]}

Chahin, Salim ^{[6
]}

Deepak, Parakkal ^{[1
]}

O'Halloran, Jane A. ^{[1
]}

Paley, Michael A. ^{[1
]}

Presti, Rachel M. ^{[1
,7
,8
]}

Wu, Gregory F. ^{[6
]}

Krammer, Florian ^{[5
]}

Alter, Galit ^{[3
]}

Ellebedy, Ali H. ^{[2
,7
,8
]}

Kim, Alfred H. J. ^{[1
,7
]}

Diamond, Michael S. ^{[1
,2
,7
,8
,9
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA

[3] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA

[4] MIT, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[5] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[6] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[7] Washington Univ, Sch Med, Andrew M & Jane M Bursky Ctr Human Immunol & Imm, St Louis, MO 63130 USA

[8] Washington Univ, Sch Med, Ctr Vaccines & Immun Microbial Pathogens, St Louis, MO 63130 USA

[9] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

来源：

MED | 2021年 / 2卷 / 12期

关键词：

INFLAMMATORY-BOWEL-DISEASE; NEUTRALIZING ANTIBODIES; IMMUNE-RESPONSE; HIGH-THROUGHPUT; INFLUENZA; IMMUNOSUPPRESSION; METHOTREXATE; EVOLUTION; REVEALS; INTACT;

D O I：

10.1016/j.medj.2021.11.004

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: Although vaccines effectively prevent coronavirus disease 2019 (COVID-19) in healthy individuals, they appear to be less immunogenic in individuals with chronic inflammatory disease (CID) or receiving chronic immunosuppression therapy. Methods: Here we assessed a cohort of 77 individuals with CID treated as monotherapy with chronic immunosuppressive drugs for antibody responses in serum against historical and variant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses after immunization with the BNT162b2 mRNA vaccine. Findings: Longitudinal analysis showed the greatest reductions in neutralizing antibodies and Fc effector function capacity in individuals treated with tumor necrosis factor alpha (TNF-alpha) inhibitors (TNFi), and this pattern appeared to be worse against the B.1.617.2 delta virus. Within 5 months of vaccination, serum neutralizing titers of all TNFi-treated individuals tested fell below the presumed threshold correlate for antibody-mediated protection. However, TNFi-treated individuals receiving a third mRNA vaccine dose boosted their serum neutralizing antibody titers by more than 16-fold. Conclusions: Vaccine boosting or administration of long-acting prophylaxis (e.g., monoclonal antibodies) will likely be required to prevent SARS-CoV-2 infection in this susceptible population.

引用

页码：1327 / +

页数：20

共 82 条

[1] Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants [J].

Abu-Raddad, Laith J. ;

Chemaitelly, Hiam ;

Butt, Adeel A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (02) :187-189

[2] SARS-CoV-2 vaccination for patients with inflammatory bowel disease: a British Society of Gastroenterology Inflammatory Bowel Disease section and IBD Clinical Research Group position statement [J].

Alexander, James L. ;

Moran, Gordon W. ;

Gaya, Daniel R. ;

Raine, Tim ;

Hart, Ailsa ;

Kennedy, Nicholas A. ;

Lindsay, James O. ;

MacDonald, Jonathan ;

Segal, Jonathan P. ;

Sebastian, Shaji ;

Selinger, Christian P. ;

Parkes, Miles ;

Smith, Philip J. ;

Dhar, Anjan ;

Subramanian, Sreedhar ;

Arasaradnam, Ramesh ;

Lamb, Christopher A. ;

Ahmad, Tariq ;

Lees, Charlie W. ;

Dobson, Liz ;

Wakeman, Ruth ;

Iqbal, Tariq H. ;

Arnott, Ian ;

Powell, Nick .

LANCET GASTROENTEROLOGY & HEPATOLOGY, 2021, 6 (03) :218-224

[3] Characterization of humoral response to COVID mRNA vaccines in multiple sclerosis patients on disease modifying therapies [J].

Ali, Ahya ;

Dwyer, Deanna ;

Wu, Qi ;

Wang, Qin ;

Dowling, Catherine A. ;

Fox, David A. ;

Khanna, Dinesh ;

Poland, Gregory A. ;

Mao-Draayer, Yang .

VACCINE, 2021, 39 (41) :6111-6116

[4]

Amanat F, 2020, NAT MED, V26, P1033, DOI [10.1038/s41591-020-0913-5, 10.1101/2020.03.17.20037713]

[5] Immune response to influenza A/H1N1 vaccine in inflammatory bowel disease patients treated with anti TNF-α agents: Effects of combined therapy with immunosuppressants [J].

Andrisani, G. ;

Frasca, D. ;

Romero, M. ;

Armuzzi, A. ;

Felice, C. ;

Marzo, M. ;

Pugliese, D. ;

Papa, A. ;

Mocci, G. ;

De Vitis, I. ;

Rapaccini, G. L. ;

Blomberg, B. B. ;

Guidi, L. .

JOURNAL OF CROHNS & COLITIS, 2013, 7 (04) :301-307

[6] Covid-19 Breakthrough Infections in Vaccinated Health Care Workers [J].

Bergwerk, Moriah ;

Gonen, Tal ;

Lustig, Yaniv ;

Amit, Sharon ;

Lipsitch, Marc ;

Cohen, Carmit ;

Mandelboim, Michal ;

Gal Levin, Einav ;

Rubin, Carmit ;

Indenbaum, Victoria ;

Tal, Ilana ;

Zavitan, Malka ;

Zuckerman, Neta ;

Bar-Chaim, Adina ;

Kreiss, Yitshak ;

Regev-Yochay, Gili .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (16) :1474-1484

[7] Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant [J].

Bernal, Jamie Lopez ;

Andrews, Nick ;

Gower, Charlotte ;

Gallagher, Eileen ;

Simmons, Ruth ;

Thelwall, Simon ;

Stowe, Julia ;

Tessier, Elise ;

Groves, Natalie ;

Dabrera, Gavin ;

Myers, Richard ;

Campbell, Colin N. J. ;

Amirthalingam, Gayatri ;

Edmunds, Matt ;

Zambon, Maria ;

Brown, Kevin E. ;

Hopkins, Susan ;

Chand, Meera ;

Ramsay, Mary .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (07) :585-594

[8] Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles [J].

Brown, Eric P. ;

Dowell, Karen G. ;

Boesch, Austin W. ;

Normandin, Erica ;

Mahan, Alison E. ;

Chu, Thach ;

Barouch, Dan H. ;

Bailey-Kellogg, Chris ;

Alter, Galit ;

Ackerman, Margaret E. .

JOURNAL OF IMMUNOLOGICAL METHODS, 2017, 443 :33-44

[9] High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samples [J].

Brown, Eric P. ;

Licht, Anna F. ;

Dugast, Anne-Sophie ;

Choi, Ickwon ;

Bailey-Kellogg, Chris ;

Alter, Galit ;

Ackerman, Margaret E. .

JOURNAL OF IMMUNOLOGICAL METHODS, 2012, 386 (1-2) :117-123

[10] A Sample-Sparing Multiplexed ADCP Assay [J].

Butler, Audrey L. ;

Fallon, Jonathan K. ;

Alter, Galit .

FRONTIERS IN IMMUNOLOGY, 2019, 10

← 1 2 3 4 5 6 7 8 9 →