Synthesis, characterization, X-ray structure and preliminary in vitro antitumor activity of the nitrosyl complex fac-[RuCl3(NO)(dppf)], dppf=1,1′-bis(diphenylphosphine)ferrocene

被引：50
作者：
Von Poelhsitz, Gustavo
Bogado, Andre Luiz
de Araujo, Marcio Peres
Selistre-de-Araujo, Heloisa S.
Ellena, Javier
Castellano, Eduardo E.
Batista, Alzir Azevedo
机构：
[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil
[2] Univ Fed Parana, Dept Quim, BR-81531990 Curitiba, Parana, Brazil
[3] Univ Fed Sao Carlos, Dept Ciencias Fisiol, BR-13565905 Sao Carlos, SP, Brazil
[4] Univ Sao Paulo, Inst Fis, BR-13560970 Sao Carlos, SP, Brazil
来源：
POLYHEDRON | 2007年 / 26卷 / 16期
基金：
巴西圣保罗研究基金会;
关键词：
nitrosyl; ruthenium; dppf; biological activity; antitumoral;
D O I：
10.1016/j.poly.2007.03.009
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The reaction of RuCl3NO center dot 2H(2)O with stoichiometric amount of dppf, 1,1'-bis(diphenylphosphino)ferrocene, afforded the new neutral nitrosyl complex fac-[RuCl3(NO)(dppf)] which was characterized by spectroscopical, electrochemical and X-ray crystallography techniques as well as elemental analysis. The nu(NO) band in the IR spectrum is at 1860 cm(-1) (CH2Cl2 solution) and in the cyclic voltammogram an irreversible wave was observed at -1.35 V, both are characteristics of a nitrosonium (NO+) character for the coordinated NO. Additionally, preliminary in vitro antitumor activity against the MDA-MB-231 breast tumor cell line was carried out for the new complex. The initial results indicated an important activity for fac-[RuCl3(NO)(dppf)] (IC50 = 10 +/- 3 mu M). The complex has a higher cytotoxicity than the precursor complex RuCl3NO center dot 2H(2)O, the free dppf ligand as well as the reference metallodrug cisplatin. (c) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：4707 / 4712
页数：6
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