A concise and convenient synthesis of stilbenes via benzils and arylmethyldiphenylphosphine oxides

被引：7

作者：

Sun Xun ^{[1
]}

Zhu Jun ^{[1
]}

Zhong Chen ^{[1
]}

Izumi, Ken-Ji ^{[1
]}

Zhang Chen ^{[1
]}

机构：

[1] Fudan Univ, Dept Chem Nat Prod, Sch Pharm, Shanghai 200032, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2007年 / 25卷 / 12期

关键词：

stilbene; substituted benzil; arylmethyldiphenylphosphine oxide; resveratrol;

D O I：

10.1002/cjoc.200790344

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new and convenient synthetic method has been developed for the construction of stilbenes bearing electron-withdrawing group(s) by using benzils and arylmethyldiphenylphosphine oxides via sequences involving Wittig-Horner reaction and a rearrangement in the presence of t-BuOK in toluene under mild conditions. This approach could be readily applied to a facile synthesis of biologically important natural products, resveratrol and its derivatives, such as trimetboxystilbenes 1 (Z) and 2 (E).

引用

页码：1866 / 1870

页数：5

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