Regulation of gene expression by HTLV-I tax protein

被引:97
作者
Bex, F [1 ]
Gaynor, RB
机构
[1] Univ Texas, SW Med Ctr, Dept Internal Med, Div Hematol Oncol, Dallas, TX 75235 USA
[2] Univ Texas, SW Med Ctr, Dept Microbiol, Div Hematol Oncol, Dallas, TX 75235 USA
[3] Univ Brussels, Dept Mol Biol, Brussels, Belgium
来源
METHODS-A COMPANION TO METHODS IN ENZYMOLOGY | 1998年 / 16卷 / 01期
关键词
D O I
10.1006/meth.1998.0646
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The human T-cell leukemia virus type I or HTLV-I is the causative agent of adult T-cell leukemia. A protein encoded by HTLV-I, Tax, activates viral gene expression and Is essential for transforming T-lymphocytes. Tax activates HTLV-I gene expression via interactions with the ATF/CREB proteins and the coactivators CBP/p300 which assemble as a multiprotein complex on regulatory elements known as 21-bp repeats in the HTLV-I LTR. Tax can also activate expression from cellular genes including the interleukin-2 (IL-2) and the IL-2 receptor genes via increases in nuclear levels of NF-kappa B. Tax modulation of gene expression via the ATF/CREB and NF-kappa B pathways is linked to its transforming properties. This review discusses the mechanisms by which Tax regulates viral and cellular gene expression. (C) 1998 Academic Press.
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页码:83 / +
页数:14
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