Bioinspired Superwettable Microspine Chips with Directional Droplet Transportation for Biosensing

被引：111

作者：

Chen, Yanxia ^{[5
]}

Li, Kan ^{[2
]}

Zhang, Shudong ^{[3
]}

Qin, Lei ^{[5
]}

Deng, Shaohui ^{[3
]}

Ge, Liyuan ^{[3
]}

Xu, Li-Ping ^{[1
]}

Ma, Lulin ^{[3
]}

Wang, Shutao ^{[2
]}

Zhang, Xueji ^{[4
]}

机构：

[1] Univ Sci & Technol Beijing, Res Ctr Bioengn & Sensing Technol, Beijing 100083, Peoples R China

[2] Chinese Acad Sci, CAS Ctr Excellence Nanosci, Tech Inst Phys & Chem, CAS Key Lab Bioinspired Mat & Interfacial Sci, Beijing 100190, Peoples R China

[3] Peking Univ, Dept Urol, Hosp 3, Beijing 100191, Peoples R China

[4] Shenzhen Univ, Sch Biomed Engn Hlth Sci Ctr, Shenzhen 518060, Guangdong, Peoples R China

[5] Beijing Informat Sci & Technol Univ, Key Lab Modern Measurement & Control Technol, Beijing Key Lab Optoelect Measurement Technol, Minist Educ,Beijing Key Lab Sensor, Beijing 100101, Peoples R China

来源：

ACS NANO | 2020年 / 14卷 / 04期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

superwettability; microfluidic chips; directional droplet transportation; gradient microchannel; biosensing; DIGITAL MICROFLUIDICS; WATER COLLECTION; SURFACE; PAPER; WETTABILITY; CANCER; CONDENSATION; PLATFORM;

D O I：

10.1021/acsnano.0c00324

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Directional droplet transportation without extra energy input remains a challenge in microfluidic biochips for clinical detections. Herein, inspired by the water-collecting behaviors on the cactus spine, we fabricate nanoinaterial-based superwettable microspine (SMS) chips. The bioinspired SMS chips are capable of spontaneous and directional droplet transportation by synergistically combining geometric asymmetry and surface superhydrophilicity. Based on theoretical models, the gradient of the Laplace pressure arising from the geometric asymmetry of the SMS chip can dominate the directional transportation of the droplet, and the superhydrophilicity of the nanomaterial-based microspine can also contribute to the droplet self-transportation. The multimicrochannel SMS chips provide a simple and energy efficient technology to realize accurate detection of serum prostate-specific antigen (PSA) from prostate cancer patients, showing great potential as a biosensing platform for clinical applications. We believe that our bioinspired superwettable two-dimensional conical surface will offer effective means for the design of smart microfluidic devices and have great potential applications in multicomponent biosensing and clinical detection.

引用

页码：4654 / 4661

页数：8

共 45 条

[1] Microfluidic heart on a chip for higher throughput pharmacological studies [J].

Agarwal, Ashutosh ;

Goss, Josue Adrian ;

Cho, Alexander ;

McCain, Megan Laura ;

Parker, Kevin Kit .

LAB ON A CHIP, 2013, 13 (18) :3599-3608

[2] Recent progress in lab-on-a-chip for pharmaceutical analysis and pharmacological/toxicological test [J].

Ai, Yongjian ;

Zhang, Feng ;

Wang, Chenlong ;

Xie, Ruoxiao ;

Liang, Qionglin .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2019, 117 :215-230

[3]

[Anonymous], 2017, ANGEW CHEM, DOI DOI 10.1002/ange.201706665

[4] Efficient Water Collection on Integrative Bioinspired Surfaces with Star-Shaped Wettability Patterns [J].

Bai, Hao ;

Wang, Lin ;

Ju, Jie ;

Sun, Ruize ;

Zheng, Yongmei ;

Jiang, Lei .

ADVANCED MATERIALS, 2014, 26 (29) :5025-5030

[5] Direction Controlled Driving of Tiny Water Drops on Bioinspired Artificial Spider Silks [J].

Bai, Hao ;

Tian, Xuelin ;

Zheng, Yongmei ;

Ju, Jie ;

Zhao, Yong ;

Jiang, Lei .

ADVANCED MATERIALS, 2010, 22 (48) :5521-5525

[6]

Berthier J., 2016, OPEN MICROFLUIDICS

[7] Continuous directional water transport on the peristome surface of Nepenthes alata [J].

Chen, Huawei ;

Zhang, Pengfei ;

Zhang, Liwen ;

Iu, Hongliang L. ;

Jiang, Ying ;

Zhang, Deyuan ;

Han, Zhiwu ;

Jiang, Lei .

NATURE, 2016, 532 (7597) :85-+

[8] Superwettable microchips with improved spot homogeneity toward sensitive biosensing [J].

Chen, Yanxia ;

Xu, Li-Ping ;

Meng, Jingxin ;

Deng, Shaohui ;

Ma, Lulin ;

Zhang, Shudong ;

Zhang, Xueji ;

Wang, Shutao .

BIOSENSORS & BIOELECTRONICS, 2018, 102 :418-424

[9] Droplet-based Biosensing for Lab-on-a-Chip, Open Microfluidics Platforms [J].

Dak, Piyush ;

Ebrahimi, Aida ;

Swaminathan, Vikhram ;

Duarte-Guevara, Carlos ;

Bashir, Rashid ;

Alam, Muhammad A. .

BIOSENSORS-BASEL, 2016, 6 (02)

[10] Past drop movements resulting from the phase change on a gradient surface [J].

Daniel, S ;

Chaudhury, MK ;

Chen, JC .

SCIENCE, 2001, 291 (5504) :633-636

← 1 2 3 4 5 →