Testosterone propionate improves motor alterations and dopaminergic damage in the reserpine-induced progressive model of Parkinson's disease

被引：6

作者：

Bispo, Jose M. M. ^{[1
]}

Melo, Joao E. C. ^{[1
]}

Gois, Auderlan M. ^{[1
]}

Medeiros, Katty A. A. L. ^{[1
]}

Silva, Rodolfo Santos ^{[1
]}

Leal, Pollyana C. ^{[1
,3
]}

Franco, Heitor S. ^{[1
]}

Souza, Marina F. ^{[1
]}

Lins, Livia C. R. F. ^{[2
]}

Ribeiro, Alessandra M. ^{[4
]}

Silva, Regina H. ^{[5
]}

Santos, Jose R. ^{[1
,6
]}

机构：

[1] Univ Fed Sergipe, Dept Biosci, Behav & Evolutionary Neurobiol Lab, Itabaiana, SE, Brazil

[2] Univ Fed Sergipe, Dept Physiol, Sao Cristovao, SE, Brazil

[3] Univ Fed Sergipe, Grad Program Dent, Aracaju, SE, Brazil

[4] Univ Fed Sao Paulo, Dept Biosci, Santos, SP, Brazil

[5] Univ Fed Sao Paulo, Dept Pharmacol, Sao Paulo, SP, Brazil

[6] Univ Fed Sergipe, Dept Biociencias, Lab Neurobiol Comportamental & Evolut, Campus Proalberto Carvalho,Ave Vereador Olimpio Gr, BR-49500000 Itabaiana, SE, Brazil

来源：

BRAIN RESEARCH BULLETIN | 2022年 / 187卷

关键词：

Parkinson?sDisease; Tyrosinehydroxylase; Neuroprotection; Androgens; OXIDATIVE STRESS; IMPAIRMENT; PARAMETERS; CATALEPSY; WEIGHT;

D O I：

10.1016/j.brainresbull.2022.06.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder with a higher susceptibility to occur in men. Studies suggest that this susceptibility is related to the hormonal differences observed between men and women, being a risk factor for PD. In addition, testosterone supplementation has shown controversial results in animal models of PD and parkinsonian patients. This study evaluated the effect of chronic adminis-tration of testosterone propionate (TP) on motor behavior and neurochemical parameters in the reserpine-induced rat model of parkinsonism. Male Wistar rats received 15 injections of reserpine (RES - 0.1 mg/kg) every other day and were concomitantly treated with different doses (0.1, 1.0, or 5.0 mg/kg) of daily TP for 30 days. The rats were euthanized 48 h after the 15th injection of RES or vehicle. Brains were removed and sub-jected to Tyrosine hydroxylase (TH) immunohistochemistry. TP at 1.0 mg/kg reduced the damages caused by reserpine in the vacuous chewing and tong protrusion behaviors and prevented dopaminergic damage in the SNpc, VTA, and Striatum. TP at 5.0 mg/kg reduced the damages caused by reserpine in the catalepsy and tong protrusion behaviors, prevented the weight loss, and prevented dopaminergic damage in the VTA. Our results suggest that chronic administration of TP has a protective effect in a rat model of parkinsonism, improving motor alterations and dopamine depletion induced by RES.

引用

页码：162 / 168

页数：7

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