Testosterone propionate improves motor alterations and dopaminergic damage in the reserpine-induced progressive model of Parkinson's disease

被引：6
作者：
Bispo, Jose M. M. [1 ]
Melo, Joao E. C. [1 ]
Gois, Auderlan M. [1 ]
Medeiros, Katty A. A. L. [1 ]
Silva, Rodolfo Santos [1 ]
Leal, Pollyana C. [1 ,3 ]
Franco, Heitor S. [1 ]
Souza, Marina F. [1 ]
Lins, Livia C. R. F. [2 ]
Ribeiro, Alessandra M. [4 ]
Silva, Regina H. [5 ]
Santos, Jose R. [1 ,6 ]
机构：
[1] Univ Fed Sergipe, Dept Biosci, Behav & Evolutionary Neurobiol Lab, Itabaiana, SE, Brazil
[2] Univ Fed Sergipe, Dept Physiol, Sao Cristovao, SE, Brazil
[3] Univ Fed Sergipe, Grad Program Dent, Aracaju, SE, Brazil
[4] Univ Fed Sao Paulo, Dept Biosci, Santos, SP, Brazil
[5] Univ Fed Sao Paulo, Dept Pharmacol, Sao Paulo, SP, Brazil
[6] Univ Fed Sergipe, Dept Biociencias, Lab Neurobiol Comportamental & Evolut, Campus Proalberto Carvalho,Ave Vereador Olimpio Gr, BR-49500000 Itabaiana, SE, Brazil
来源：
BRAIN RESEARCH BULLETIN | 2022年 / 187卷
关键词：
Parkinson?sDisease; Tyrosinehydroxylase; Neuroprotection; Androgens; OXIDATIVE STRESS; IMPAIRMENT; PARAMETERS; CATALEPSY; WEIGHT;
D O I：
10.1016/j.brainresbull.2022.06.018
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder with a higher susceptibility to occur in men. Studies suggest that this susceptibility is related to the hormonal differences observed between men and women, being a risk factor for PD. In addition, testosterone supplementation has shown controversial results in animal models of PD and parkinsonian patients. This study evaluated the effect of chronic adminis-tration of testosterone propionate (TP) on motor behavior and neurochemical parameters in the reserpine-induced rat model of parkinsonism. Male Wistar rats received 15 injections of reserpine (RES - 0.1 mg/kg) every other day and were concomitantly treated with different doses (0.1, 1.0, or 5.0 mg/kg) of daily TP for 30 days. The rats were euthanized 48 h after the 15th injection of RES or vehicle. Brains were removed and sub-jected to Tyrosine hydroxylase (TH) immunohistochemistry. TP at 1.0 mg/kg reduced the damages caused by reserpine in the vacuous chewing and tong protrusion behaviors and prevented dopaminergic damage in the SNpc, VTA, and Striatum. TP at 5.0 mg/kg reduced the damages caused by reserpine in the catalepsy and tong protrusion behaviors, prevented the weight loss, and prevented dopaminergic damage in the VTA. Our results suggest that chronic administration of TP has a protective effect in a rat model of parkinsonism, improving motor alterations and dopamine depletion induced by RES.
引用
收藏
页码：162 / 168
页数：7
相关论文
共 68 条
  • [11] Meta-analyses on prevalence of selected Parkinson's nonmotor symptoms before and after diagnosis
    Chen, Honglei
    Zhao, Edward J.
    Zhang, Wen
    Lu, Yi
    Liu, Rui
    Huang, Xuemei
    Ciesielski-Jones, Anna J.
    Justice, Michele A.
    Cousins, Deborah S.
    Peddada, Shyamal
    [J]. TRANSLATIONAL NEURODEGENERATION, 2015, 4
  • [12] Testosterone deprivation intensifies cognitive decline in obese male rats via glial hyperactivity, increased oxidative stress, and apoptosis in both hippocampus and cortex
    Chunchai, Titikorn
    Apaijai, Nattayaporn
    Keawtep, Puntarik
    Mantor, Duangkamol
    Arinno, Apiwan
    Pratchayasakul, Wasana
    Chattipakorn, Nipon
    Chattipakorn, Siriporn C.
    [J]. ACTA PHYSIOLOGICA, 2019, 226 (01)
  • [13] Testosterone Propionate Exacerbates the Deficits of Nigrostriatal Dopaminergic System and Downregulates Nrf2 Expression in Reserpine-Treated Aged Male Rats
    Cui, Rui
    Kang, Yunxiao
    Wang, Li
    Li, Shuangcheng
    Ji, Xiaoming
    Yan, Wensheng
    Zhang, Guoliang
    Cui, Huixian
    Shi, Geming
    [J]. FRONTIERS IN AGING NEUROSCIENCE, 2017, 9
  • [14] Amelioratory effects of testosterone propionate supplement on behavioral, biochemical and morphological parameters in aged rats
    Cui, Rui
    Zhang, Guoliang
    Kang, Yunxiao
    Cheng, Qinglong
    Tan, Huibing
    Cui, Huixian
    Shi, Geming
    [J]. EXPERIMENTAL GERONTOLOGY, 2012, 47 (01) : 67 - 76
  • [15] Androgens exacerbate motor asymmetry in male rats with unilateral 6-hydroxydopamine lesion
    Cunningham, Rebecca L.
    Macheda, Teresa
    Watts, Lora Talley
    Poteet, Ethan
    Singh, Meharvan
    Roberts, James L.
    Giuffrida, Andrea
    [J]. HORMONES AND BEHAVIOR, 2011, 60 (05) : 617 - 624
  • [16] Androgens Induce Dopaminergic Neurotoxicity via Caspase-3-Dependent Activation of Protein Kinase Cδ
    Cunningham, Rebecca L.
    Giuffrida, Andrea
    Roberts, James L.
    [J]. ENDOCRINOLOGY, 2009, 150 (12) : 5539 - 5548
  • [17] Episodic recognition memory and the hippocampus in Parkinson's disease: A review
    Das, Tanusree
    Hwang, Jaclyn J.
    Poston, Kathleen L.
    [J]. CORTEX, 2019, 113 : 191 - 209
  • [18] Parkinson's disease: Mechanisms and models
    Dauer, W
    Przedborski, S
    [J]. NEURON, 2003, 39 (06) : 889 - 909
  • [19] DLUZEN D, 1994, J NEUROCHEM, V62, P94
  • [20] Balance alterations and reduction of pedunculopontine cholinergic neurons in early stages of parkinsonism in middle-aged rats
    dos Santos, Thassya F. O.
    Santos, Edson de R.
    Bispo, Jose M. M.
    de Souza, Marina F.
    de Gois, Auderlan M.
    Lins, Livia C. R. F.
    Silva, Regina H.
    Ribeiro, Alessandra M.
    Marchioro, Murilo
    dos Santos, Jose R.
    [J]. EXPERIMENTAL GERONTOLOGY, 2021, 145
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