A surface-acoustic-wave-based cantilever bio-sensor

被引：15
作者：
De Simoni, Giorgio [1 ]
Signore, Giovanni [1 ]
Agostini, Matteo [1 ,2 ]
Beltram, Fabio [2 ]
Piazza, Vincenzo [1 ]
机构：
[1] Ist Italian Tecnol, Ctr Nanotechnol Innovat NEST, I-56127 Pisa, Italy
[2] Scuola Normale Super Pisa, NEST, I-56127 Pisa, Italy
来源：
BIOSENSORS & BIOELECTRONICS | 2015年 / 68卷
关键词：
Cantilever bio-sensor; Surface acoustic wave; NANOMECHANICAL DETECTION; MICROCANTILEVER; BINDING; NANOPARTICLE; ASSAY;
D O I：
10.1016/j.bios.2014.12.058
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A scalable surface-acoustic-wave- (SAW-) based cantilevered device for portable bio-chemical sensing applications is presented. Even in the current, proof-of-principle implementation this architecture is shown to outperform commercial quartz-crystal microbalances in terms of sensitivity. Adhesion of analytes on a functionalized surface of the cantilever shifts the resonant frequency of a SAW-generating transducer due to the stress-induced variation of the speed of surface acoustic modes. We discuss the relevance of this approach for diagnostics applications based on miniaturized devices. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：570 / 576
页数：7
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