Development of nanomaterials for bone-targeted drug delivery

被引：109

作者：

Cheng, Hao ^{[1
,2
,3
]}

Chewla, Aditya ^{[1
,2
,4
]}

Yang, Yafeng ^{[1
,2
]}

Li, Yuxiao ^{[1
,2
]}

Zhang, Jin ^{[1
,2
]}

Jang, Hae Lin ^{[1
,2
,4
]}

Khademhosseini, Ali ^{[1
,2
,4
,5
,6
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Div Biomed Engn, Dept Med,Biomat Innovat Res Ctr, Boston, MA 02139 USA

[2] MIT, Div Hlth Sci & Technol, Harvard Massachusetts Inst Technol, Cambridge, MA 02139 USA

[3] Huazhong Univ Sci & Technol, Tongji Hosp, Orthopaed Dept, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

[4] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[5] Konkuk Univ, Dept Bioind Technol, Coll Anim Biosci & Technol, Seoul 143701, South Korea

[6] King Abdulaziz Univ, Dept Phys, Jeddah 21569, Saudi Arabia

来源：

DRUG DISCOVERY TODAY | 2017年 / 22卷 / 09期

基金：

美国国家卫生研究院;

关键词：

MESOPOROUS SILICA NANOPARTICLES; ENDOPLASMIC-RETICULUM STRESS; BIOACTIVE GLASS NANOPARTICLES; NONVIRAL GENE DELIVERY; OF-THE-ART; GOLD NANOPARTICLES; IN-VITRO; OSTEOCLAST DIFFERENTIATION; MULTIFUNCTIONAL NANOPARTICLES; MORPHOGENETIC PROTEIN-2;

D O I：

10.1016/j.drudis.2017.04.021

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bone is one of the major organs of the human body; it supports and protects other organs, produces blood cells, stores minerals, and regulates hormones. Therefore, disorders in bone can cause serious morbidity, complications, or mortality of patients. However, despite the significant occurrence of bone diseases, such as osteoarthritis (OA), osteoporosis (OP), non-union bone defects, bone cancer, and myeloma-related bone disease, their effective treatments remain a challenge. In this review, we highlight recent progress in the development of nanotechnology-based drug delivery for bone treatment, based on its improved delivery efficiency and safety. We summarize the most commonly used nanomaterials for bone drug delivery. We then discuss the targeting strategies of these nanomaterials to the diseased sites of bone tissue. We also highlight nanotechnology-based drug delivery to bone cells and subcellular organelles. We envision that nanotechnology-based drug delivery will serve as a powerful tool for developing treatments for currently incurable bone diseases.

引用

页码：1336 / 1350

页数：15