EFFECTS OF RESISTANCE EXERCISE COMBINED WITH ESSENTIAL AMINO ACID SUPPLEMENTATION AND ENERGY DEFICIT ON MARKERS OF SKELETAL MUSCLE ATROPHY AND REGENERATION DURING BED REST AND ACTIVE RECOVERY

被引：45

作者：

Brooks, Naomi E. ^{[2
]}

Cadena, Samuel M. ^{[3
]}

Vannier, Edouard ^{[4
]}

Cloutier, Gregory ^{[3
]}

Carambula, Silvia ^{[3
]}

Myburgh, Kathryn H. ^{[2
]}

Roubenoff, Ronenn ^{[1
]}

Castaneda-Sceppa, Carmen ^{[1
,5
]}

机构：

[1] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA

[2] Univ Stellenbosch, Dept Physiol Sci, ZA-7600 Stellenbosch, South Africa

[3] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA

[4] Tufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA USA

[5] Northeastern Univ, Bouve Coll Hlth Sci, Boston, MA 02115 USA

来源：

MUSCLE & NERVE | 2010年 / 42卷 / 06期

基金：

美国国家卫生研究院; 新加坡国家研究基金会;

关键词：

bed rest; energy deficit; essential amino acid supplementation; myogenic factors; resistance exercise; MESSENGER-RNA EXPRESSION; SATELLITE CELLS; MYOSTATIN; SIZE; HUMANS; MASS; SPACEFLIGHT; MICE;

D O I：

10.1002/mus.21780

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Spaceflight and bed rest (BR) lead to muscle atrophy. This study assessed the effect of essential amino acid (EAA) supplementation and resistance training with decreased energy intake on molecular changes in skeletal muscle after 28-day BR and 14-day recovery. Thirty-one men (31-55 years) subjected to an 8 +/- 6% energy deficit were randomized to receive EAA without resistance training (AA, n = 7), or EAA 3 h after (RT, n = 12) or 5 min before (AART, n = 12) resistance training. During BR, myostatin transcript levels increased twofold in the AA group. During recovery, insulin-like growth factor-1 (IGF-1) mRNA increased in all groups, whereas Pax7, MyoD, myogenin, and MRF4 transcripts increased in AA only (all P < 0.05). MAFbx transcripts decreased twofold with AA and RT. Satellite cells did not change during BR or recovery. This suggests that EAA alone is the least protective countermeasure to muscle loss, and several molecular mechanisms are proposed by which exercise attenuates muscle atrophy during BR with energy deficit. Muscle Nerve 42: 927-935, 2010

引用

页码：927 / 935

页数：9

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