Targeted anticancer drug delivery through anthracycline antibiotic bearing functionalized quantum dots

被引：18

作者：

Bajwa, Neha ^{[1
]}

Mehra, Neelesh Kumar ^{[1
,2
]}

Jain, Keerti ^{[1
]}

Jain, Narendra Kumar ^{[1
]}

机构：

[1] ISF Coll Pharm, Pharmaceut Nanotechnol Res Lab, Moga, Punjab, India

[2] Texas A&M Hlth Sci Ctr, Irma Lerma Rangel Coll Pharm, Dept Pharmaceut Sci, Kingsville, TX 78363 USA

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2016年 / 44卷 / 07期

关键词：

Chitosan; doxorubicin HCL; folic acid; imaging; quantum dots; targeting; DOXORUBICIN DELIVERY; CARBON NANOTUBES; THERAPY;

D O I：

10.3109/21691401.2015.1102740

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We herein first report a method for the synthesis of chitosan (CHI)-folate conjugated colloidal ZnO-Mn+2 quantum dots (QDs) bearing doxorubicin through chemical method (DOX/FA-CHI-QDs) for cancer therapy as well imaging purpose. The entrapment efficiency was determined to be 99.98 +/- 0.012% (DOX/FA-CHI-QDs) and 92.0 +/- 2.62% (DOX-QDs). The developed DOX/FA-CHI-QDs formulations depict the sustained release pattern at the lysosomal pH (pH 5.0). The DOX/FA-CHI-QDs showed enhanced cytotoxicity, cellular uptake and were most preferentially taken up by the cancerous cells via receptor-mediated endocytosis (RME) mechanism. Hence, the QD-based formulation is capable of targeting drug delivery and imaging the delivery process.

引用

页码：1774 / 1782

页数：9

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