Heart-Ankle Pulse Wave Velocity Is Superior to Brachial-Ankle Pulse Wave Velocity in Detecting Aldosterone-Induced Arterial Stiffness

被引：7

作者：

Chen, Zheng-Wei ^{[1
,2
,3
]}

Pan, Chien-Ting ^{[1
,2
,3
]}

Tsai, Cheng-Hsuan ^{[1
,2
,4
]}

Chang, Yi-Yao ^{[5
]}

Chang, Chin-Chen ^{[6
,7
]}

Lee, Bo-Ching ^{[6
,7
]}

Chiu, Yu-Wei ^{[5
,8
]}

Huang, Wei-Chieh ^{[9
]}

Lin, Yu-Li ^{[10
,11
]}

Wu, Vin-Cent ^{[1
,2
]}

Hung, Chi-Sheng ^{[1
,2
]}

Liao, Che-Wei ^{[1
,2
,12
]}

Lin, Yen-Hung ^{[1
,2
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

[2] Natl Taiwan Univ, Coll Med, Taipei 100, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Internal Med, Yun Lin Branch, Yunlin 640, Taiwan

[4] Natl Taiwan Univ Hosp, Dept Internal Med, Jin Shan Branch, New Taipei 208, Taiwan

[5] Far Eastern Mem Hosp, Dept Cardiovasc Med, New Taipei 220, Taiwan

[6] Natl Taiwan Univ Hosp, Coll Med, Dept Med Imaging, Taipei 100, Taiwan

[7] Natl Taiwan Univ, Taipei 100, Taiwan

[8] Yuan Ze Univ, Dept Comp Sci & Engn, Taoyuan 320, Taiwan

[9] Taipei Vet Gen Hosp, Div Cardiol, Dept Internal Med, Taipei 112, Taiwan

[10] Chihlee Univ Technol, Dept Business Adm, New Taipei 220, Taiwan

[11] Chihlee Univ Technol, Grad Sch Serv Management, New Taipei 220, Taiwan

[12] Natl Taiwan Univ, Canc Ctr, Dept Med, Taipei 106, Taiwan

来源：

BIOMEDICINES | 2021年 / 9卷 / 10期

关键词：

primary aldosteronism; arterial stiffness; brachial-ankle pulse wave velocity; heart-ankle pulse wave velocity; INTIMA-MEDIA THICKNESS; VASCULAR INDEX; WALL STIFFNESS; CARDIOVASCULAR EVENTS; CARDIO; DIAGNOSIS; RECOMMENDATIONS; HYPERTENSION; PREVALENCE; PREDICTION;

D O I：

10.3390/biomedicines9101285

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Primary aldosteronism (PA) is associated with higher arterial stiffness compared to essential hypertension (EH). However, few studies have compared different pulse wave velocity (PWV) parameters to detect aldosterone-induced arterial stiffness. In this study, we aimed to compare the sensitivity in detecting aldosterone-induced arterial stiffness between brachial-ankle PWV (baPWV) and heart-ankle PWV (haPWV). We prospectively enrolled 1006 PA patients and 983 EH patients. Detailed medical history, basic biochemistry data and two PWV measurements (baPWV and haPWV) were collected in both groups. We performed analysis on the original cohort and two propensity score matching (PSM) models (model 1 adjusted for age and sex; model 2 adjusted for age, sex, systolic and diastolic blood pressure). The DeLong test was used to compare areas under receiver operating characteristic curves (AUCs) between baPWV and haPWV to predict PA. In all models, the PA patients had significantly higher baPWV compared to the EH patients. The AUC of haPWV was greater than that of baPWV. In conclusion, haPWV seems to be a better PWV parameter than baPWV in detecting aldosterone-induced arterial stiffness.</p>

引用

页数：11

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