Immune Cell Population in Ovarian Tumor Microenvironment

被引:57
作者
Cai, Dong Li [1 ,2 ]
Jin, Li-Ping [1 ,2 ]
机构
[1] Tongji Univ, Sch Med, Clin & Translat Res Ctr, Shanghai Matern & Infant Hosp 1, West Gaoke Rd 2699, Shanghai 201204, Peoples R China
[2] Fudan Univ, Hosp Obstet & Gynecol, Lab Reprod Immunol, Shanghai Med Coll, Shanghai 200011, Peoples R China
来源
JOURNAL OF CANCER | 2017年 / 8卷 / 15期
基金
中国国家自然科学基金;
关键词
ovarian cancer; tumor microenvironment; immune cell population; REGULATORY T-CELLS; ENDOTHELIAL GROWTH-FACTOR; CANCER-CELLS; DENDRITIC CELLS; POOR-PROGNOSIS; INHIBITORY FACTOR; TNF-ALPHA; MACROPHAGES; EXPRESSION; CARCINOMA;
D O I
10.7150/jca.20314
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Ovarian cancer, the third most common with highest mortality rates gynecological malignancy among women in China, is characterized by a unique tumor immune microenvironment. Immune-cell population infiltrated into the tumor tissue among patients with ovarian cancer are associated positively or negatively with antitumor activity. The imbalance between immune activation and immune suppression can result in oncogenesis and cancer progression. Therefore, intense investigation of the immunologic mechanism of ovarian cancer is urgently needed, and a comprehensive understanding of the network in which immune cells interact with the microenvironment, tumor cells and each other will greatly promote the development of more effective immunotherapies for ovarian cancer. In this review, we will focus on the main immune-cell population in ovarian tumor microenvironment, discuss their role in tumor progression and try to give the readers a new perspective in finding more promising therapeutic targets for cancers.
引用
收藏
页码:2915 / 2923
页数:9
相关论文
共 90 条
  • [1] T Cell Density and Location Can Influence the Prognosis of Ovarian Cancer
    Al-Attar, Ahmad
    Shehata, Mohamed
    Durrant, Lindy
    Moseley, Paul
    Deen, Suha
    Chan, Stephen
    [J]. PATHOLOGY & ONCOLOGY RESEARCH, 2010, 16 (03) : 361 - 370
  • [2] Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages
    Allavena, P.
    Chieppa, M.
    Bianchi, G.
    Solinas, G.
    Fabbri, M.
    Laskarin, G.
    Mantovani, A.
    [J]. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2010,
  • [3] Therapeutic targets and new directions for antibodies developed for ovarian cancer
    Bax, Heather J.
    Josephs, Debra H.
    Pellizzari, Giulia
    Spicer, James F.
    Montes, Ana
    Karagiannis, Sophia N.
    [J]. MABS, 2016, 8 (08) : 1437 - 1455
  • [4] Combined Immunoscore of CD103 and CD3 Identifies Long-Term Survivors in High-Grade Serous Ovarian Cancer
    Boesmueller, Hans-Christian
    Wagner, Philipp
    Peper, Janet Kerstin
    Schuster, Heiko
    Deborah Lam Pham
    Greif, Karen
    Beschorner, Christine
    Rammensee, Hans-Georg
    Stevanovie, Stefan
    Fend, Falko
    Staebler, Annette
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2016, 26 (04) : 671 - 679
  • [5] Effects of vascular endothelial growth factor on the lymphocyte-endothelium interactions: Identification of caveolin-1 and nitric oxide as control points of endothelial cell anergy
    Bouzin, Caroline
    Brouet, Agnes
    De Vriese, Joelle
    DeWever, Julie
    Feron, Olivier
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 178 (03) : 1505 - 1511
  • [6] Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy
    Buckanovich, Ronald J.
    Facciabene, Andrea
    Kim, Sarah
    Benencia, Fabian
    Sasaroli, Dimitra
    Balint, Klara
    Katsaros, Dionysios
    O'Brien-Jenkins, Anne
    Gimotty, Phyllis A.
    Coukos, George
    [J]. NATURE MEDICINE, 2008, 14 (01) : 28 - 36
  • [7] Chambers SK, 1997, CLIN CANCER RES, V3, P999
  • [8] Chatterjee J, 2016, CLIN CANC RES
  • [9] Ovarian Cancer Cells Induce Peripheral Mature Dendritic Cells to Differentiate Into Macrophagelike Cells In Vitro
    Chen, Fangxue
    Hou, Meng
    Ye, Feng
    Lv, Weiguo
    Xie, Xing
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2009, 19 (09) : 1487 - 1493
  • [10] Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3
    Chen, WJ
    Jin, WW
    Hardegen, N
    Lei, KJ
    Li, L
    Marinos, N
    McGrady, G
    Wahl, SM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (12) : 1875 - 1886