Role of Noncoding RNA in Pulmonary Arterial Hypertension and Potential Drug Therapeutic Target

被引：10

作者：

Zhang, Chi-yuan ^{[1
]}

Liu, Mo ^{[2
]}

Wan, Jia-ming ^{[3
]}

Gao, Ming-qi ^{[2
]}

Zhang, Yue ^{[3
]}

Soyan, Muscab ^{[3
]}

Wang, Huai-liang ^{[2
]}

Bai, Yang ^{[2
]}

机构：

[1] China Med Univ, Shengjing Hosp, Dept Obstet & Gynecol, Shenyang, Liaoning, Peoples R China

[2] China Med Univ, Dept Clin Pharmacol, Coll Pharm, 77 Puhe Rd, Shenyang, Liaoning, Peoples R China

[3] China Med Univ, Shenyang 110122, Liaoning, Peoples R China

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2018年 / 18卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Pulmonary arterial hypertension; noncoding RNA; drugs; miRNA; LncRNA; network; SMOOTH-MUSCLE-CELLS; VASOACTIVE-INTESTINAL-PEPTIDE; CIRCULAR RNAS; DOWN-REGULATION; NITRIC-OXIDE; IMMUNE-RESPONSE; UP-REGULATION; BETA-CATENIN; MOUSE MODEL; HYPOXIA;

D O I：

10.2174/1568026618666180719162124

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Pulmonary arterial hypertension (PAH) is a devastating disease without effective drugs available for its treatment. An in-depth exploration of the pathogenesis of PAH, as well as inquiry into potential therapeutic targets, remains an urgent issue. Non-coding RNAs (ncRNAs) have arisen as key players in malignant tumors, cardiovascular diseases and more recently in PAH progression and development. Network pharmacology is a new discipline based on system biology, which can predict potential therapeutic targets in diseases regulated by multiple genes. In this review, we discuss the current knowledge of ncRNAs and network pharmacology regulated genes involved in PAH, as well as the search for potential drug targets for PAH.

引用

页码：975 / 986

页数：12

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