Management of hereditary thyroid cancer in children

被引：18

作者：

Skinner, MA ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Durham, NC 27710 USA

来源：

SURGICAL ONCOLOGY-OXFORD | 2003年 / 12卷 / 02期

关键词：

medullary thyroid carcinoma; RET protooncogene; multiple endocrine neoplasia;

D O I：

10.1016/S0960-7404(03)00033-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hereditary thyroid cancer in childhood occurs in the setting of Multiple Endocrine Neoplasia types 2A and 2B, and familial medullary thyroid carcinoma, FMTC. Prophylactic thyroidectomy in childhood has been recommended in patients found to have inherited mutations in the RET protooncogene, to prevent the development of medullary thyroid carcinoma. In this report are presented the clinical and genetic aspects of hereditary thyroid cancer in children, as well as surgical recommendations and medium-term outcome results. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：101 / 104

页数：4

相关论文

共 34 条

[1] GFRα1 is an essential receptor component for GDNF in the developing nervous system and kidney [J].

Cacalano, G ;

Fariñas, I ;

Wang, LC ;

Hagler, K ;

Forgie, A ;

Moore, M ;

Armanini, M ;

Phillips, H ;

Ryan, AM ;

Reichardt, LF ;

Hynes, M ;

Davies, A ;

Rosenthal, A .

NEURON, 1998, 21 (01) :53-62

[2]

Carlomagno F, 2002, CANCER RES, V62, P7284

[3] SINGLE MISSENSE MUTATION IN THE TYROSINE KINASE CATALYTIC DOMAIN OF THE RET PROTOONCOGENE IS ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE 2B [J].

CARLSON, KM ;

DOU, SS ;

CHI, D ;

SCAVARDA, N ;

TOSHIMA, K ;

JACKSON, CE ;

WELLS, SA ;

GOODFELLOW, PJ ;

DONISKELLER, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (04) :1579-1583

[4] MUTATIONS IN THE RET PROTOONCOGENE ARE ASSOCIATED WITH MEN 2A AND FMTC [J].

DONISKELLER, H ;

DOU, SS ;

CHI, D ;

CARLSON, KM ;

TOSHIMA, K ;

LAIRMORE, TC ;

HOWE, JR ;

MOLEY, JF ;

GOODFELLOW, P ;

WELLS, SA .

HUMAN MOLECULAR GENETICS, 1993, 2 (07) :851-856

[5] POINT MUTATION WITHIN THE TYROSINE KINASE DOMAIN OF THE RET PROTOONCOGENE IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 2B AND RELATED SPORADIC TUMORS [J].

ENG, C ;

SMITH, DP ;

MULLIGAN, LM ;

NAGAI, MA ;

HEALEY, CS ;

PONDER, MA ;

GARDNER, E ;

SCHEUMANN, GFW ;

JACKSON, CE ;

TUNNACLIFFE, A ;

PONDER, BAJ .

HUMAN MOLECULAR GENETICS, 1994, 3 (02) :237-241

[6] GFRα1-deficient mice have deficits in the enteric nervous system and kidneys [J].

Enomoto, H ;

Araki, T ;

Jackman, A ;

Heuckeroth, RO ;

Snider, WD ;

Johnson, EM ;

Milbrandt, J .

NEURON, 1998, 21 (02) :317-324

[7] Various penetrance of familial medullary thyroid carcinoma in patients with RET protooncogene codon 790/791 germline mutations [J].

Fitze, G ;

Schierz, M ;

Bredow, J ;

Saeger, HD ;

Roesner, D ;

Schackert, HK .

ANNALS OF SURGERY, 2002, 236 (05) :570-575

[8]

Friedel GH, 1961, CANCER, V15, P241

[9] Multiple endocrine neoplasia type 2 and RET:: from neoplasia to neurogenesis [J].

Hansford, JR ;

Mulligan, LM .

JOURNAL OF MEDICAL GENETICS, 2000, 37 (11) :817-827

[10] A MUTATION IN THE RET PROTOONCOGENE ASSOCIATED WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE-2B AND SPORADIC MEDULLARY-THYROID CARCINOMA [J].

HOFSTRA, RMW ;

LANDSVATER, RM ;

CECCHERINI, I ;

STULP, RP ;

STELWAGEN, T ;

LUO, Y ;

PASINI, B ;

HOPPENER, JWM ;

VANAMSTEL, HKP ;

ROMEO, G ;

LIPS, CJM ;

BUYS, CHCM .

NATURE, 1994, 367 (6461) :375-376

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