Stereochemistry of terpene derivatives. Part 7: Novel rigidified amino acids from (+)-3-carene designed as chiral GABA analogues

被引：17

作者：

Gajcy, Kamila ^{[1
]}

Pekala, Jolanta ^{[1
]}

Frackowiak-Wojtasek, Bozena ^{[2
]}

Librowski, Tadeusz ^{[3
]}

Lochynski, Stanislaw ^{[1
,4
]}

机构：

[1] Wroclaw Univ Technol, Dept Bioorgan Chem, Fac Chem, PL-50370 Wroclaw, Poland

[2] Opole Univ, Fac Chem, PL-45052 Opole, Poland

[3] Jagiellonian Univ, Dept Pharmacodynam, Coll Med, PL-30688 Krakow, Poland

[4] Wroclaw Coll Physiotherapy, Dept Cosmetol, PL-50038 Wroclaw, Poland

来源：

TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 16期

关键词：

GAMMA-PEPTIDES; HELIX FORMATION; INHIBITION; NANOTUBES;

D O I：

10.1016/j.tetasy.2010.06.026

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Several novel cyclopropyl-rigidified gamma- and delta-amino acids 3-4 have been prepared starting from monoterpene (+)-3-carene 2. These compounds are proposed as chiral analogues of gamma-aminobutyric acid (GABA) 1 and are expected to be of interest as potential inhibitors of GABA receptors. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2015 / 2020

页数：6

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