Circular RNAs and their emerging roles as diagnostic and prognostic biomarkers in ovarian cancer

被引：65
作者：
Sheng, Rong [1 ]
Li, Xiaoduan [2 ]
Wang, Ziliang [1 ]
Wang, Xipeng [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Dept Obstet & Gynecol, Xinhua Hosp, Sch Med, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China
[2] Tongji Univ, Sch Med, Shanghai Matern & Infant Hosp 1, Dept Gynecol, Shanghai 200092, Peoples R China
来源：
CANCER LETTERS | 2020年 / 473卷
基金：
中国国家自然科学基金;
关键词：
MicroRNA sponge; Therapeutic target; EMT; Heterogeneity; Exosome; PROMOTES CELL-PROLIFERATION; SUPPRESSES PROLIFERATION; EXPRESSION; METASTASIS; TRANSLATION; BIOGENESIS; CIRCHIPK3; EXOSOMES; INVASION; SPONGE;
D O I：
10.1016/j.canlet.2019.12.043
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian cancer (OC), one of the gynecologic malignancies with high invasive and metastatic potential, has a low survival rate in females. Although cytoreductive surgery combined with chemotherapy is the principal treatment for OC, the prognosis remains poor, and the recurrence rate of OC remains high. It is urgent to explore novel biomarkers for the diagnosis and prognosis of OC, as well as therapeutic targets. Circular RNAs (circRNAs) are a class of highly conserved, stable and abundant noncoding RNAs (ncRNAs). Recent studies have shown that circRNAs participate in OC progression by regulating various processes, including cell proliferation, migration, invasion and apoptosis. In addition, circRNAs are potential biomarkers for OC diagnosis and prognosis. This review provides an overview of recent findings on circRNAs in OC, including their functions and molecular mechanisms, and discusses their potential roles as diagnostic and prognostic biomarkers, as well as therapeutic targets for OC.
引用
收藏
页码：139 / 147
页数：9
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