Multivalent Aptamer-modified DNA Origami as Drug Delivery System for Targeted Cancer Therapy

被引：33

作者：

Cao Mengyao ^{[1
]}

Sun Yueyang ^{[1
]}

Xiao Mingshu ^{[1
]}

Li Li ^{[1
]}

Liu Xiaohui ^{[2
]}

Jin Hong ^{[2
]}

Pei Hao ^{[1
]}

机构：

[1] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200241, Peoples R China

[2] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2020年 / 36卷 / 02期

关键词：

DNA origami; Targeted drug delivery system; Aptamer; NANOPARTICLES; THERAPEUTICS; NANOFLOWERS; DESIGN;

D O I：

10.1007/s40242-019-9273-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In spite of great development in nanoparticle-based drug delivery systems(DDSs) for improved therapeutic efficacy, it remains challenging for effective delivery of chemotherapeutic drugs to targeted tumor cells. In this work, we report a triangle DNA origami as targeted DDS for cancer therapy. DNA origami shows excellent biocompatibility and stability in cell culture medium for 24 h. In addition, the DNA origami structures conjugated with multivalent aptamers enable for efficient delivery of anticancer drug doxorubicin(Dox) into targeted cancer cell due to their targeting function, reducing side effects associated with nonspecific distribution. Moreover, we also demonstrated that the multivalent aptamer-modified DNA origami loading Dox exhibits prominent therapeutic efficacy in vitro. Accordingly, this work provides a good paradigm for the development of DNA origami nanostructure-based targeted DDS for cancer therapy.

引用

页码：254 / 260

页数：7

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