Traditional on-board gateways have many shortcomings, such as response speed, transmission bandwidth, data processing performance, and software portability. In view of these shortcomings, this paper proposes an on-board gateway design method based on Open CPU. The business logic is transferred from MCU to Open CPU, and the collection of body data information is isolated from the gateway function, so as to realize a new on-board gateway system. In this paper, Open CPU is used to design the on-board gateway system, which has the advantages of fast response speed, high transmission bandwidth, good data processing performance and strong software portability. The test table shows that the system has a good real-time performance and improves the response speed and transmission efficiency.