A new approach to fluorinated 4(3H)-quinazolinones

被引：22
|
作者：
Layeva, Anastacia A.
Nosova, Emilia V.
Lipunova, Galina N.
Trashakhova, Tatyana V.
Charushin, Valerii N.
机构：
[1] Russian Acad Sci, I Ya Postovskiy Inst Organ Synth, Ural Div, Ekaterinburg 620219, Russia
[2] Ural State Tech Univ, Ekaterinburg 620002, Russia
来源：
JOURNAL OF FLUORINE CHEMISTRY | 2007年 / 128卷 / 07期
基金：
俄罗斯基础研究基金会;
关键词：
fluorine-containing quinazolinones; intramolecular cyclization; nucleophilic substitution; S-ethyl N-benzoylisothioureas;
D O I：
10.1016/j.jfluchem.2007.03.005
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new approach for the synthesis of fluorinated 1H-quinazolin-4-ones and 4-substituted quinazolines has been developed. 6-Fluoro-1H-quinazolin-4-ones were obtained by intramolecular cyclization of fluorine-containing S-ethyl N-benzoylisothioureas. Nucleophilic substitution reactions at positions 2 and 7, as well as alkylation at I-position of quinazolinones were investigated. In addition, the synthesis of fluorine-containing 4-aminoquinazolines was carried out. (c) 2007 Published by Elsevier B.V.
引用
收藏
页码：748 / 754
页数：7
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