Vitamin D supplementation has no effects on progression of motor dysfunction in amyotrophic lateral sclerosis (ALS)

被引:22
作者
Trojsi, Francesca [1 ]
Siciliano, Mattia [1 ,2 ]
Passaniti, Carla [1 ,2 ]
Bisecco, Alvino [1 ]
Russo, Antonio [1 ]
Lavorgna, Luigi [1 ]
Esposito, Sabrina [1 ]
Ricciardi, Dario [1 ]
Monsurro, Maria Rosaria [1 ]
Tedeschi, Gioacchino [1 ]
Santangelo, Gabriella [2 ]
机构
[1] Univ Campania Luigi Vanvitelli, MRI Res Ctr SUN FISM, Dept Adv Med & Surg Sci, Naples, Italy
[2] Univ Campania Luigi Vanvitelli, Dept Psychol, Caserta, Italy
关键词
CONTROLLED-TRIAL; ALZHEIMERS; SAFETY; RISK; DEFICIENCY;
D O I
10.1038/s41430-019-0448-3
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objectives To investigate the effects of cholecalciferol supplementation on the progression of motor disability in a cohort of amyotrophic lateral sclerosis (ALS) patients with low blood 25-hydroxyvitamin D3 [25(OH)D] levels, on the basis of the hypothesis of potential neuroprotective effects of vitamin D supplementation. Methods Forty-eight ALS patients, 34 with deficient (<20 ng/mL) and 14 with insufficient (20-29 ng/mL) serum levels of 25(OH)D, were randomized and treated by 3 different doses of cholecalciferol [50.000, 75.000 and 100.000 international units (IU) /month] and evaluated after 6-months. Assessment of motor dysfunction at baseline and after 6 months included ALS Functional Rating Scale-Revised (ALFRS-R) and upper motor neuron (UMN) scores and blood samples for 25(OH)D levels. Results Clinical data of 33 patients were available after 6 months. Analysis of Covariance (ANCOVA), with pre-treatment measurements included as covariate, did not show statistically significant differences in the ALSFRS-R (p > 0.05) and UMN (p > 0.05) among the patient groups who underwent 3 different doses of cholecalciferol. Conversely, the treatment with 75.000 IU/month or 100.000 IU/month induced a significant increase in serum levels of 25(OH)D in comparison with the supplementation with 50.000 IU/month; no significant differences were found between 75.000 IU/month and 100.000 IU/month. Conclusions Our findings highlighted that 6-month supplementation of vitamin D in ALS patients had no significant effects on motor dysfunction. However, it is recommended to prevent medical complications of vitamin D deficiency in ALS patients as well as in other populations of neurodegenerative patients, characterized by low mobility and decreased sun exposure.
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页码:167 / 175
页数:9
相关论文
共 45 条
[1]   Vitamin D as an Early Predictor of Multiple Sclerosis Activity and Progression [J].
Ascherio, Alberto ;
Munger, Kassandra L. ;
White, Rick ;
Koechert, Karl ;
Simon, Kelly Claire ;
Polman, Chris H. ;
Freedman, Mark S. ;
Hartung, Hans-Peter ;
Miller, David H. ;
Montalban, Xavier ;
Edan, Gilles ;
Barkhof, Frederik ;
Pleimes, Dirk ;
Radue, Ernst-Wilhelm ;
Sandbrink, Rupert ;
Kappos, Ludwig ;
Pohl, Christoph .
JAMA NEUROLOGY, 2014, 71 (03) :306-314
[2]   National Osteoporosis Society Vitamin D Guideline Summary [J].
Aspray, Terry J. ;
Bowring, Claire ;
Fraser, William ;
Gittoes, Neil ;
Javaid, M. Kassim ;
Macdonald, Helen ;
Patel, Sanjeev ;
Selby, Peter ;
Tanna, Nuttan ;
Francis, Roger M. .
AGE AND AGEING, 2014, 43 (05) :592-595
[3]   Progesterone with Vitamin D Affords Better Neuroprotection against Excitotoxicity in Cultured Cortical Neurons than Progesterone Alone [J].
Atif, Fahim ;
Sayeed, Iqbal ;
Ishrat, Tauheed ;
Stein, Donald G. .
MOLECULAR MEDICINE, 2009, 15 (9-10) :328-336
[4]   1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls [J].
Bhargava, Pavan ;
Gocke, Anne ;
Calabresi, Peter A. .
JOURNAL OF NEUROIMMUNOLOGY, 2015, 279 :20-24
[5]   Vitamin D is Not a Protective Factor in ALS [J].
Blasco, Helene ;
Hounoum, Blandine Madji ;
Dufour-Rainfray, Diane ;
Patin, Franck ;
Maillot, Francois ;
Beltran, Stephane ;
Gordon, Paul H. ;
Andres, Christian R. ;
Corcia, Philippe .
CNS NEUROSCIENCE & THERAPEUTICS, 2015, 21 (08) :651-656
[6]   El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis [J].
Brooks, BR ;
Miller, RG ;
Swash, M ;
Munsat, TL .
AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS, 2000, 1 (05) :293-299
[7]   Vitamin D and the regulation of Wnt/β-catenin signaling and innate immunity in colorectal cancer [J].
Byers, Stephen ;
Shah, Salim .
NUTRITION REVIEWS, 2007, 65 (08) :S118-S120
[8]   Vitamin D confers protection to motoneurons and is a prognostic factor of amyotrophic lateral sclerosis [J].
Camu, William ;
Tremblier, Boris ;
Plassot, Carine ;
Alphandery, Sebastien ;
Salsac, Celine ;
Pageot, Nicolas ;
Juntas-Morales, Raul ;
Scamps, Frederique ;
Daures, Jean-Pierre ;
Raoul, Cedric .
NEUROBIOLOGY OF AGING, 2014, 35 (05) :1198-1205
[9]   Vitamin D and inflammation [J].
Cannell, John J. ;
Grant, William B. ;
Holick, Michael F. .
DERMATO-ENDOCRINOLOGY, 2014, 6 (01)
[10]   The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function [J].
Cedarbaum, JM ;
Stambler, N ;
Malta, E ;
Fuller, C ;
Hilt, D ;
Thurmond, B ;
Nakanishi, A .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1999, 169 (1-2) :13-21