Nuclear-Targeted Drug Delivery of TAT Peptide-Conjugated Monodisperse Mesoporous Silica Nanoparticles

被引：880
作者：
Pan, Limin [1 ]
He, Qianjun [1 ]
Liu, Jianan [1 ]
Chen, Yu [1 ]
Ma, Ming [1 ]
Zhang, Linlin [1 ]
Shi, Jianlin [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 13期
基金：
中国国家自然科学基金;
关键词：
PORE COMPLEX; DNA-DAMAGE; TRANSPORT; DOXORUBICIN; CELLS;
D O I：
10.1021/ja211035w
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Most present nanodrug delivery systems have been developed to target cancer cells but rarely nuclei. However, nuclear-targeted drug delivery is expected to kill cancer cells more directly and efficiently. In this work, TAT peptide has been employed to conjugate onto mesoporous silica nanoparticles (MSNs-TAT) with high payload for nuclear-targeted drug delivery for the first time. Monodispersed MSNs-TAT of varied particle sizes have been synthesized to investigate the effects of particle size and TAT conjugation on the nuclear membrane penetrability of MSNs. MSNs-TAT with a diameter of 50 nm or smaller can efficiently target the nucleus and deliver the active anticancer drug doxorubicin (DOX) into the targeted nucleus, killing these cancer cells with much enhanced efficiencies. This study may provide an effective strategy for the design and development of cell-nuclear-targeted drug delivery.
引用
收藏
页码：5722 / 5725
页数：4
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