Three-component coupling using arynes and aminosilanes for ortho-selective double functionalization of aromatic skeletons

被引：43

作者：

Morishita, Takami ^{[1
]}

Fukushima, Hiroyuki ^{[1
]}

Yoshida, Hiroto ^{[1
]}

Ohshita, Joji ^{[1
]}

Kunai, Atsutaka ^{[1
]}

机构：

[1] Hiroshima Univ, Dept Appl Chem, Grad Sch Engn, Higashihiroshima 7398527, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 14期

关键词：

D O I：

10.1021/jo800761b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Arynes were found to couple with aminosilanes and carbonyl compounds in the presence of benzoic acid to provide 2-aminobenzhydrols. Sulfonylimines could also be applied to the reaction, enabling amino and aminomethyl moieties to be incorporated into contiguous positions of aromatic skeletons. Only a small amount of the three-component coupling product was obtained in the absence of benzoic acid, which confirms its vital role in the present reaction.

引用

页码：5452 / 5457

页数：6

共 53 条

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (34) :11040-11041

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