Although many anticancer therapies are successful in killing a large percentage of tumor cells when initially administered, the evolutionary dynamics underpinning tumor progression mean that, often, resistance is an inevitable outcome. Research in the field of ecology suggests that an evolutionary double bind could be an effective way to treat tumors. In an evolutionary double bind two therapies are used in combination such that evolving resistance to one leaves individuals more susceptible to the other. In this paper we present a general evolutionary game theory framework of a double bind to study the effect that such an approach would have in cancer. Furthermore we use this mathematical framework to understand recent experimental results that suggest a synergistic effect between a p53 cancer vaccine and chemotherapy. Our model recapitulates the latest experimental data and provides an explanation for its effectiveness based on the commensalistic relationship between the tumor phenotypes.
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Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
Basanta, David
;
Scott, Jacob G.
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Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
Scott, Jacob G.
;
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Rockne, Russ
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Swanson, Kristin R.
论文数: 0引用数: 0
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Univ Washington, Seattle, WA 98104 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
Swanson, Kristin R.
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Anderson, Alexander R. A.
论文数: 0引用数: 0
h-index: 0
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Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
机构:
Mayo Clin, Div Hematol, Coll Med, Rochester, MN 55905 USAMayo Clin, Div Hematol, Coll Med, Rochester, MN 55905 USA
Dingli, D.
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Chalub, F. A. C. C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, Dept Matemat, P-2829516 Caparica, Portugal
Ctr Matemat & Aplicacoes, P-2829516 Caparica, PortugalMayo Clin, Div Hematol, Coll Med, Rochester, MN 55905 USA
Chalub, F. A. C. C.
;
Santos, F. C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Libre Bruxelles, IRIDIA, CoDE, B-1050 Brussels, BelgiumMayo Clin, Div Hematol, Coll Med, Rochester, MN 55905 USA
Santos, F. C.
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Van Segbroeck, S.
论文数: 0引用数: 0
h-index: 0
机构:
Vrije Univ Brussel, COMO, B-1050 Brussels, BelgiumMayo Clin, Div Hematol, Coll Med, Rochester, MN 55905 USA
Van Segbroeck, S.
;
Pacheco, J. M.
论文数: 0引用数: 0
h-index: 0
机构:
CFTC, ATP Grp, P-1649003 Lisbon, Portugal
Fac Ciencias Lisboa, Dept Fis, P-1649003 Lisbon, PortugalMayo Clin, Div Hematol, Coll Med, Rochester, MN 55905 USA
机构:
H Lee Moffitt Canc Ctr & Res Inst, Dept Radiol, Tampa, FL 33612 USA
H Lee Moffitt Canc Ctr & Res Inst, Dept Integrat Math Oncol, Tampa, FL 33612 USAH Lee Moffitt Canc Ctr & Res Inst, Dept Radiol, Tampa, FL 33612 USA
Gatenby, Robert A.
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Brown, Joel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Ecol & Evolut Biol, Chicago, IL USAH Lee Moffitt Canc Ctr & Res Inst, Dept Radiol, Tampa, FL 33612 USA
Brown, Joel
;
Vincent, Thomas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Aerosp Engn, Tucson, AZ USAH Lee Moffitt Canc Ctr & Res Inst, Dept Radiol, Tampa, FL 33612 USA
机构:
Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
Basanta, David
;
Scott, Jacob G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
Scott, Jacob G.
;
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机构:
Rockne, Russ
;
Swanson, Kristin R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Seattle, WA 98104 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
Swanson, Kristin R.
;
Anderson, Alexander R. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
机构:
Mayo Clin, Div Hematol, Coll Med, Rochester, MN 55905 USAMayo Clin, Div Hematol, Coll Med, Rochester, MN 55905 USA
Dingli, D.
;
Chalub, F. A. C. C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, Dept Matemat, P-2829516 Caparica, Portugal
Ctr Matemat & Aplicacoes, P-2829516 Caparica, PortugalMayo Clin, Div Hematol, Coll Med, Rochester, MN 55905 USA
Chalub, F. A. C. C.
;
Santos, F. C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Libre Bruxelles, IRIDIA, CoDE, B-1050 Brussels, BelgiumMayo Clin, Div Hematol, Coll Med, Rochester, MN 55905 USA
Santos, F. C.
;
Van Segbroeck, S.
论文数: 0引用数: 0
h-index: 0
机构:
Vrije Univ Brussel, COMO, B-1050 Brussels, BelgiumMayo Clin, Div Hematol, Coll Med, Rochester, MN 55905 USA
Van Segbroeck, S.
;
Pacheco, J. M.
论文数: 0引用数: 0
h-index: 0
机构:
CFTC, ATP Grp, P-1649003 Lisbon, Portugal
Fac Ciencias Lisboa, Dept Fis, P-1649003 Lisbon, PortugalMayo Clin, Div Hematol, Coll Med, Rochester, MN 55905 USA
机构:
H Lee Moffitt Canc Ctr & Res Inst, Dept Radiol, Tampa, FL 33612 USA
H Lee Moffitt Canc Ctr & Res Inst, Dept Integrat Math Oncol, Tampa, FL 33612 USAH Lee Moffitt Canc Ctr & Res Inst, Dept Radiol, Tampa, FL 33612 USA
Gatenby, Robert A.
;
Brown, Joel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Ecol & Evolut Biol, Chicago, IL USAH Lee Moffitt Canc Ctr & Res Inst, Dept Radiol, Tampa, FL 33612 USA
Brown, Joel
;
Vincent, Thomas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Aerosp Engn, Tucson, AZ USAH Lee Moffitt Canc Ctr & Res Inst, Dept Radiol, Tampa, FL 33612 USA