Exploiting Evolution To Treat Drug Resistance: Combination Therapy and the Double Bind

被引:114
作者
Basanta, David [1 ]
Gatenby, Robert A. [1 ]
Anderson, Alexander R. A. [1 ]
机构
[1] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
关键词
evolutionary game theory; evolutionary double bind; mathematical modeling; immunotherapy; chemotherapy; combination therapy; comensalism; GAME;
D O I
10.1021/mp200458e
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Although many anticancer therapies are successful in killing a large percentage of tumor cells when initially administered, the evolutionary dynamics underpinning tumor progression mean that, often, resistance is an inevitable outcome. Research in the field of ecology suggests that an evolutionary double bind could be an effective way to treat tumors. In an evolutionary double bind two therapies are used in combination such that evolving resistance to one leaves individuals more susceptible to the other. In this paper we present a general evolutionary game theory framework of a double bind to study the effect that such an approach would have in cancer. Furthermore we use this mathematical framework to understand recent experimental results that suggest a synergistic effect between a p53 cancer vaccine and chemotherapy. Our model recapitulates the latest experimental data and provides an explanation for its effectiveness based on the commensalistic relationship between the tumor phenotypes.
引用
收藏
页码:914 / 921
页数:8
相关论文
共 15 条
[1]   Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment [J].
Anderson, Alexander R. A. ;
Weaver, Alissa M. ;
Cummings, Peter T. ;
Quaranta, Vito .
CELL, 2006, 127 (05) :905-915
[2]   Microenvironmental Independence Associated with Tumor Progression [J].
Anderson, Alexander R. A. ;
Hassanein, Mohamed ;
Branch, Kevin M. ;
Lu, Jenny ;
Lobdell, Nichole A. ;
Maier, Julie ;
Basanta, David ;
Weidow, Brandy ;
Narasanna, Archana ;
Arteaga, Carlos L. ;
Reynolds, Albert B. ;
Quaranta, Vito ;
Estrada, Lourdes ;
Weaver, Alissa M. .
CANCER RESEARCH, 2009, 69 (22) :8797-8806
[3]   Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer [J].
Antonia, SJ ;
Mirza, N ;
Fricke, I ;
Chiappori, A ;
Thompson, P ;
Williams, N ;
Bepler, G ;
Simon, G ;
Janssen, W ;
Lee, JH ;
Menander, K ;
Chada, S ;
Gabrilovich, DI .
CLINICAL CANCER RESEARCH, 2006, 12 (03) :878-887
[4]   Evolutionary game theory elucidates the role of glycolysis in glioma progression and invasion [J].
Basanta, D. ;
Simon, M. ;
Hatzikirou, H. ;
Deutsch, A. .
CELL PROLIFERATION, 2008, 41 (06) :980-987
[5]   The role of IDH1 mutated tumour cells in secondary glioblastomas: an evolutionary game theoretical view [J].
Basanta, David ;
Scott, Jacob G. ;
Rockne, Russ ;
Swanson, Kristin R. ;
Anderson, Alexander R. A. .
PHYSICAL BIOLOGY, 2011, 8 (01)
[6]   Cancer phenotype as the outcome of an evolutionary game between normal and malignant cells [J].
Dingli, D. ;
Chalub, F. A. C. C. ;
Santos, F. C. ;
Van Segbroeck, S. ;
Pacheco, J. M. .
BRITISH JOURNAL OF CANCER, 2009, 101 (07) :1130-1136
[7]  
Gatenby RA, 2003, CANCER RES, V63, P6212
[8]   Lessons from Applied Ecology: Cancer Control Using an Evolutionary Double Bind [J].
Gatenby, Robert A. ;
Brown, Joel ;
Vincent, Thomas .
CANCER RESEARCH, 2009, 69 (19) :7499-7502
[9]   p53 gene status modulates the chemosensitivity of non-small cell lung cancer cells [J].
Lai, SL ;
Perng, RP ;
Hwang, JL .
JOURNAL OF BIOMEDICAL SCIENCE, 2000, 7 (01) :64-70
[10]  
Maynard Smith J., 1982, pi